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https://hdl.handle.net/2440/50752
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dc.contributor.author | Hayakawa, K. | - |
dc.contributor.author | Hiramatsu, N. | - |
dc.contributor.author | Okamura, M. | - |
dc.contributor.author | Yao, J. | - |
dc.contributor.author | Paton, A. | - |
dc.contributor.author | Paton, J. | - |
dc.contributor.author | Kitamura, M. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 2008; 365(1):47-53 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | http://hdl.handle.net/2440/50752 | - |
dc.description | Copyright © 2008 Elsevier Inc. All rights reserved. | - |
dc.description.abstract | Geranylgeranylacetone (GGA), an anti-ulcer agent, has anti-inflammatory potential against experimental colitis and ischemia-induced renal inflammation. However, molecular mechanisms involved in its anti-inflammatory effects are largely unknown. We found that, in glomerular mesangial cells, GGA blocked activation of nuclear factor-κB and consequent induction of monocyte chemoattractant protein 1 (MCP-1) by inflammatory cytokines. It was inversely correlated with induction of unfolded protein response (UPR) evidenced by expression of 78 kDa glucose-regulated protein (GRP78) and suppression of endoplasmic reticulum stress-responsive alkaline phosphatase. Various inducers of UPR including tunicamycin, thapsigargin, A23187, 2-deoxyglucose, dithiothreitol, and AB5 subtilase cytotoxin reproduced the suppressive effects of GGA. Furthermore, attenuation of UPR by stable transfection with GRP78 diminished the anti-inflammatory effects of GGA. These results disclosed a novel, UPR-dependent mechanism underlying the anti-inflammatory potential of GGA. | - |
dc.description.statementofresponsibility | Kunihiro Hayakawa, Nobuhiko Hiramatsu, Maro Okamura, Jian Yao, Adrienne W. Paton, James C. Paton and Masanori Kitamura | - |
dc.language.iso | en | - |
dc.publisher | Academic Press Inc | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bbrc.2007.10.115 | - |
dc.subject | Geranylgeranylacetone | - |
dc.subject | Mesangial cell | - |
dc.subject | Tumor necrosis factor-α | - |
dc.subject | Unfolded protein response | - |
dc.subject | Endoplasmic reticulum stress | - |
dc.subject | Monocyte chemoattractant protein 1 | - |
dc.subject | Nuclear factor-κB | - |
dc.title | Blunted activation of NF-kappa B and NF-kappa B-dependent gene expression by geranylgeranylacetone: Involvement of unfolded protein response | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bbrc.2007.10.115 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Paton, J. [0000-0001-9807-5278] | - |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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