Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/50945
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Type: Journal article
Title: Validity of medication-based co-morbidity indices in the Australian elderly population
Author: Vitry, A.
Wong, S.
Roughead, E.
Ramsay, E.
Barratt, J.
Citation: Australian and New Zealand Journal of Public Health, 2009; 33(2):126-130
Publisher: Public Health Assoc Australia Inc
Issue Date: 2009
ISSN: 1326-0200
1753-6405
Statement of
Responsibility: 
Agnes Vitry, Soo Ann Wong, Elizabeth E. Roughead, Emmae Ramsay, John Barratt
Abstract: OBJECTIVES: To determine the validity of two medication-based co-morbidity indices, the Medicines Disease Burden Index (MDBI) and Rx-Risk-V in the Australian elderly population. METHODS: In Phase I, the sensitivity and specificity of both indices were determined in 767 respondents from wave 6 of the Australian Longitudinal Study of Ageing (ALSA). Medication-defined index disease categories were compared to self-reported medical conditions. Correlation with self-rated health was examined and Cox proportional hazards models were used to assess the predictive validity for mortality. Phase II verified the predictive ability of Rx-Risk-V in a sample of 213,191 veterans from Australian Department of Veterans' Affairs (DVA) database. RESULTS: MDBI and Rx-Risk-V scores could be calculated for 28% and 73% of the ALSA sample respectively. Both indices had high specificities and low to moderate sensitivities compared to self-reported medical conditions. Total weighted scores were significantly related to self-rated health (p<0.001). Both indices were predictive of mortality (Hazard Ratio (HR) =3.690 (95% CI 2.264-6.015) for MDBI and HR 1.079 (95% CI 1.045-1.114) for Rx-Risk-V. The predictive validity for mortality of Rx-Risk-V was confirmed using DVA data (HR= 1.090, 95% CI 1.088-1.092). CONCLUSIONS: Medication-based co-morbidity indices Rx-Risk-V and MDBI are valid measures of co-morbidity. However, Rx-Risk-V detects more comorbidity in the Australian elderly population and is likely to be a more suitable index to use in administrative datasets, particularly where studies include large numbers of outpatients.
Keywords: co-morbidity; chronic disease/drug therapy; drug prescriptions; risk adjustment/methods
Description: © 2009 The Authors. Journal Compilation © 2009 Public Health Association of Australia
RMID: 0020090554
DOI: 10.1111/j.1753-6405.2009.00357.x
Appears in Collections:Public Health publications

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