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dc.contributor.authorCavuoto, P.en
dc.contributor.authorWittert, G.en
dc.identifier.citationBest Practice & Research Clinical Endocrinology & Metabolism, 2009; 23(1):79-86en
dc.description.abstractEndocannabinoids, a lipid-derived signaling system, regulate appetite and motivation to eat via effects in the hypothalamus and nucleus accumbens. Not all the effects of endocannabinoids on fat mass can be explained by the regulation of food intake alone. Endocannabinoids and their receptors are located in areas of the central nervous system and multiple peripheral tissues involved in the regulation of intermediary metabolism and energy expenditure. In addition to regulating food intake by both central and peripherally mediated effects, endocannabinoids modify glucose and lipid metabolism so as to promote energy storage via lipogenesis and reduce energy expenditure. The endocannabinoid system appears to be overactive in obesity and may serve to maintain fat mass and underlies some of the metabolic consequences of obesity. Inhibition of the cannabinoid type-1 receptor ameliorates the effects of endocannabinoids on food intake and energy metabolism; lipogenesis is inhibited, lipolysis, fatty acid oxidation and glucose uptake increase.en
dc.description.statementofresponsibilityPaul Cavuoto and Gary A. Witterten
dc.publisherBailliere Tindallen
dc.subjectendocannabinoid; energy expenditure; anandamide; 2-arachidonyl glycerol; CB1; metabolismen
dc.titleThe role of the endocannabinoid system in the regulation of energy expenditureen
dc.typeJournal articleen
pubs.library.collectionMedicine publicationsen
dc.identifier.orcidWittert, G. [0000-0001-6818-6065]en
Appears in Collections:Medicine publications

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