Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51528
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Type: Journal article
Title: Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: Association with PTSD
Author: Metzger, L.
Clark, C.
McFarlane, A.
Veltmeyer, M.
Lasko, M.
Paige, S.
Pitman, R.
Orr, S.
Citation: Psychophysiology, 2009; 46(1):172-178
Publisher: Cambridge Univ Press
Issue Date: 2009
ISSN: 0048-5772
1469-8986
Statement of
Responsibility: 
Linda J. Metzger, C. Richard Clark, Alexander C. Mcfarlane, Melinda D. Veltmeyer, Natasha B. Lasko, Stephen R. Paige, Roger K. Pitman and Scott P. Orr
Abstract: Studies have demonstrated ERP abnormalities related to concentration difficulties in post-traumatic stress disorder (PTSD). We used an identical-twin, case-control design to investigate whether these abnormalities reflect pre-trauma vulnerability or the acquired consequence of PTSD. Vietnam combat veterans and their non-combat-exposed, identical twins completed a three-tone oddball task. Veterans with PTSD had delayed target N2 latencies compared to veterans without PTSD. In a small nonmedicated, nonsmoking subsample, veterans with PTSD also had significantly diminished target P3b amplitudes. A mixed-model, random-effects analysis on the nonmedicated, nonsmoking subsample that included the combat-unexposed co-twins showed a significant Diagnosis x Combat Exposure interaction for target P3b amplitude. Results replicate increased N2 latency and diminished P3b amplitude in PTSD and suggest that diminished P3b amplitude is an acquired condition in PTSD.
Keywords: Twin studies; Post-traumatic stress disorder; Event-related potentials; P3b
RMID: 0020090028
DOI: 10.1111/j.1469-8986.2008.00720.x
Appears in Collections:Psychiatry publications

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