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https://hdl.handle.net/2440/51528
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dc.contributor.author | Metzger, L. | - |
dc.contributor.author | Clark, C. | - |
dc.contributor.author | McFarlane, A. | - |
dc.contributor.author | Veltmeyer, M. | - |
dc.contributor.author | Lasko, M. | - |
dc.contributor.author | Paige, S. | - |
dc.contributor.author | Pitman, R. | - |
dc.contributor.author | Orr, S. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | Psychophysiology, 2009; 46(1):172-178 | - |
dc.identifier.issn | 0048-5772 | - |
dc.identifier.issn | 1469-8986 | - |
dc.identifier.uri | http://hdl.handle.net/2440/51528 | - |
dc.description.abstract | Studies have demonstrated ERP abnormalities related to concentration difficulties in post-traumatic stress disorder (PTSD). We used an identical-twin, case-control design to investigate whether these abnormalities reflect pre-trauma vulnerability or the acquired consequence of PTSD. Vietnam combat veterans and their non-combat-exposed, identical twins completed a three-tone oddball task. Veterans with PTSD had delayed target N2 latencies compared to veterans without PTSD. In a small nonmedicated, nonsmoking subsample, veterans with PTSD also had significantly diminished target P3b amplitudes. A mixed-model, random-effects analysis on the nonmedicated, nonsmoking subsample that included the combat-unexposed co-twins showed a significant Diagnosis x Combat Exposure interaction for target P3b amplitude. Results replicate increased N2 latency and diminished P3b amplitude in PTSD and suggest that diminished P3b amplitude is an acquired condition in PTSD. | - |
dc.description.statementofresponsibility | Linda J. Metzger, C. Richard Clark, Alexander C. Mcfarlane, Melinda D. Veltmeyer, Natasha B. Lasko, Stephen R. Paige, Roger K. Pitman and Scott P. Orr | - |
dc.language.iso | en | - |
dc.publisher | Cambridge Univ Press | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1469-8986.2008.00720.x | - |
dc.subject | Twin studies | - |
dc.subject | Post-traumatic stress disorder | - |
dc.subject | Event-related potentials | - |
dc.subject | P3b | - |
dc.title | Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: Association with PTSD | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1469-8986.2008.00720.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | McFarlane, A. [0000-0002-3829-9509] | - |
Appears in Collections: | Aurora harvest 5 Psychiatry publications |
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