Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51877
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Type: Journal article
Title: Micromechanical properties of human trabecular bone: A hierarchical investigation using nanoindentation
Author: Norman, J.
Shapter, J.
Short, K.
Smith, L.
Fazzalari, N.
Citation: Journal of Biomedical Materials Research. Part A, 2008; 87A(1):196-202
Publisher: John Wiley & Sons, Inc.
Issue Date: 2008
ISSN: 1549-3296
1552-4965
Statement of
Responsibility: 
Jonathan Norman, Joe G. Shapter, Ken Short, Lachlan J. Smith and Nicola L. Fazzalari
Abstract: The ability to assess the risk of fracture, evaluate new therapies, predict implant success and assess the influence of bone remodeling disorders requires specific measurement of local bone micromechanical properties. Nanoindentation is an established tool for assessing the micromechanical properties of hard biological tissues. In this study, elastic modulus and hardness were quantified using nanoindentation for human trabecular bone from the intertrochanteric region of the proximal femur. These properties were demonstrated to be heterogeneous and highly correlated at the intraspicule, interspicule, and interspecimen levels. The results of this study have important implications for current understanding of structure-function relationships throughout the trabecular bone structural hierarchy.
Keywords: trabecular bone; structural hierarchy; micromechanical properties; nanoindentation
Description: Copyright © 2008 Wiley Periodicals, Inc., A Wiley Company
RMID: 0020082630
DOI: 10.1002/jbm.a.31766
Appears in Collections:Pathology publications

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