Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/52168
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Type: Journal article
Title: Bone remodeling: A review of the bone microenvironment perspective for fragility fracture (osteoporosis) of the hip
Author: Fazzalari, N.
Citation: Seminars in Cell & Developmental Biology, 2008; 19(5):467-472
Publisher: Academic Press Ltd
Issue Date: 2008
ISSN: 1084-9521
1096-3634
Statement of
Responsibility: 
Nicola L. Fazzalari
Abstract: Bone remodeling is an active process throughout the skeleton. The concept of bone turnover surface has been developed and reported in the peer reviewed literature as the quotient of formation surface/resorption surface and is significantly lower in hip fracture. It is necessary to identify the molecular drivers of these changes in bone turnover. Factors that have been strongly implicated in bone metabolism are therefore divided into three categories, "Vascular", "Anabolic" and "Catabolic". Further data is required from the bone tissue-level microenvironment, of fragility fracture patients, on the variation in molecular signals, and the associated changes in bone structure and remodeling.
Keywords: Bone and Bones; Humans; Osteoporosis; Hip Fractures; Intercellular Signaling Peptides and Proteins; Bone Remodeling; Female
Description: Crown copyright © 2008 Published by Elsevier Ltd.
RMID: 0020083606
DOI: 10.1016/j.semcdb.2008.08.003
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/622944/description#description
Appears in Collections:Pathology publications

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