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|Title:||An unusual MR signal reduction artefact in an incompletely thawed cadaver spine specimen|
|Citation:||Radiography, 2009; 15(1):86-90|
|Publisher:||W.B. Saunders Co. Ltd.|
|Andrew P. Kurmis, John P. Slavotinek, Christine Barber, Lachlan Smith and Nicola L. Fazzalari|
|Abstract:||Objective: Within the contemporary constraints associated with in vivo use for research purposes, preservation of macroscopic human tissue specimens is of critical importance. Simple sub-zero freezing remains the method-of-choice for medium-term storage of such material. Despite widespread use, few papers have described the effects of this preservation method on resultant images, or the impact of inadequate tissue thawing. Materials and methods: A series of post-mortem-harvested human lumbar spine specimens were undergoing conventional MR imaging as part of a larger project exploring non-invasive hydration status assessment of the intervertebral disc. Results: A complex central signal reduction artefact was noted during scanning of one specimen, resembling an isotherm distribution. Subtle inadequacies in core specimen thawing lead to an initially confusing pattern of central signal dampening. Conclusions: These findings demonstrate the impact of sub-optimal specimen preparation on image signal characteristics and highlight the importance of appropriate thawing methods of frozen tissue specimens prior to imaging.|
|Keywords:||MR artefact; Imaging artefact; Isotherm; Signal dampening; Spine imaging; Signal artefact|
|Rights:||Copyright © 2008 The College of Radiographers Published by Elsevier Ltd.|
|Appears in Collections:||Pathology publications|
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