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https://hdl.handle.net/2440/52591
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dc.contributor.author | Gibson, A. | - |
dc.contributor.author | Degenhardt, L. | - |
dc.contributor.author | Mattick, R. | - |
dc.contributor.author | Ali, R. | - |
dc.contributor.author | White, J. | - |
dc.contributor.author | O'Brien, S. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Addiction, 2008; 103(3):462-468 | - |
dc.identifier.issn | 0965-2140 | - |
dc.identifier.issn | 1360-0443 | - |
dc.identifier.uri | http://hdl.handle.net/2440/52591 | - |
dc.description.abstract | <h4>Aims</h4>To (i) examine the predictors of mortality in a randomized study of methadone versus buprenorphine maintenance treatment; (ii) compare the survival experience of the randomized subject groups; and (iii) describe the causes of death.<h4>Design</h4>Ten-year longitudinal follow-up of mortality among participants in a randomized trial of methadone versus buprenorphine maintenance treatment.<h4>Setting</h4>Recruitment through three clinics for a randomized trial of buprenorphine versus methadone maintenance.<h4>Participants</h4>A total of 405 heroin-dependent (DSM-IV) participants aged 18 years and above who consented to participate in original study.<h4>Measurements</h4>Baseline data from original randomized study; dates and causes of death through data linkage with Births, Deaths and Marriages registries; and longitudinal treatment exposure via State health departments. Predictors of mortality examined through survival analysis.<h4>Findings</h4>There was an overall mortality rate of 8.84 deaths per 1000 person-years of follow-up and causes of death were comparable with the literature. Increased exposure to episodes of opioid treatment longer than 7 days reduced the risk of mortality; there was no differential mortality among methadone versus buprenorphine participants. More dependent, heavier users of heroin at baseline had a lower risk of death, and also higher exposure to opioid treatment. Older participants randomized to buprenorphine treatment had significantly improved survival. Aboriginal or Torres Strait Islander participants had a higher risk of death.<h4>Conclusions</h4>Increased exposure to opioid maintenance treatment reduces the risk of death in opioid-dependent people. There was no differential reduction between buprenorphine and methadone. Previous studies suggesting differential effects may have been affected by biases in patient selection. | - |
dc.description.statementofresponsibility | Amy Gibson, Louisa Degenhardt, Richard P. Mattick, Robert Ali, Jason White & Susannah O’Brien | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Publishing Ltd | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1360-0443.2007.02090.x | - |
dc.subject | Buprenorphine | - |
dc.subject | longitudinal | - |
dc.subject | maintenance treatment | - |
dc.subject | methadone | - |
dc.subject | mortality | - |
dc.subject | opioid dependence | - |
dc.subject | RCT. | - |
dc.title | Exposure to opioid maintenance treatment reduces long-term mortality | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1360-0443.2007.02090.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ali, R. [0000-0003-2905-8153] | - |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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