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Type: Journal article
Title: Maternal insulin-like growth factor-II promotes placental functional development via the type 2 IGF receptor in the guinea pig
Author: Sferruzzi-Perri, A.
Owens, J.
Standen, P.
Roberts, C.
Citation: Placenta, 2008; 29(4):347-355
Publisher: W B Saunders Co Ltd
Issue Date: 2008
ISSN: 0143-4004
Statement of
A.N. Sferruzzi-Perri, J.A. Owens, P. Standen and C.T. Roberts
Abstract: In guinea pigs, maternal insulin-like growth factor (IGF) infusion in early-pregnancy enhances placental transport near-term, increasing fetal growth and survival. The effects of IGF-II, but not IGF-I, appear due to enhanced placental labyrinthine (exchange) development. To determine if the type-2 IGF receptor (IGF2R) mediates these distinct actions of exogenous IGF-II in the mother, we compared the impact of IGF-II with an IGF-II analogue, Leu(27)-IGF-II, which only binds the IGF2R. IGF-II, Leu(27)-IGF-II (1mg/kg per or vehicle were infused from days 20-38 of pregnancy (term = 67 days) and placental structure and uptake and transfer of [(3)H]-methyl-D-glucose (MG) and [(14)C]-amino-isobutyric acid (AIB) and fetal growth and plasma metabolites, were measured on day 62. Both IGF-II and Leu(27)-IGF-II increased the volume of placental labyrinth, trophoblast and maternal blood space within the labyrinth and total surface area of trophoblast for exchange, compared to vehicle. Leu(27)-IGF-II also reduced the barrier to diffusion (trophoblast thickness) compared to vehicle and IGF-II. Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. In addition, Leu(27)-IGF-II increased fetal weight compared to vehicle. In conclusion, maternal treatment with IGF-II or Leu(27)-IGF-II in early gestation, induce similar placental and fetal outcomes near term. This suggests that maternal IGF-II in early gestation acts in part via the IGF2R to persistently enhance placental functional development and nutrient delivery and promote fetal growth.
Keywords: Blood Vessels; Adipose Tissue; Trophoblasts; Fetus; Placenta; Animals; Guinea Pigs; Body Weight; Fetal Weight; Aminoisobutyric Acids; 3-O-Methylglucose; Amino Acids; Insulin-Like Growth Factor II; Receptor, IGF Type 2; Organ Size; Body Composition; Biological Transport; Pregnancy; Maternal-Fetal Exchange; Placentation; Litter Size; Female
Description: Copyright © 2008 Elsevier Ltd All rights reserved.
RMID: 0020080536
DOI: 10.1016/j.placenta.2008.01.009
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Appears in Collections:Obstetrics and Gynaecology publications

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