Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5339
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dc.contributor.authorLawrenson, J.en
dc.contributor.authorGhabriel, M.en
dc.contributor.authorReid, A.en
dc.contributor.authorGajree, T.en
dc.contributor.authorAllt, G.en
dc.date.issued1995en
dc.identifier.citationBritish Journal of Ophthalmology, 1995; 79(5):462-466en
dc.identifier.issn0007-1161en
dc.identifier.issn1468-2079en
dc.identifier.urihttp://hdl.handle.net/2440/5339-
dc.description.abstractBACKGROUND--A rat endothelial barrier antigen (EBA) recognised by a monoclonal antibody has been shown to be expressed strongly by endothelial cells of brain capillaries possessing a blood-brain barrier and only weakly expressed by fenestrated brain vessels. METHODS--In this study immunocytochemical methods for light and electron microscopy were used to study EBA distribution in the eye and orbital tissues of the rat. RESULTS--Blood-ocular barrier vessels in the optic nerve, retina, iris, and some vessels in th choroid and ciliary body were immunopositive for EBA. By pre-embedding immunocytochemistry for electron microscopy the antigen was observed on the luminal endothelial cell surface. CONCLUSION--Surprisingly, some non-barrier vessels in the ciliary body and choroid expressed EBA suggesting that it may play a broader role in endothelial properties than previously recognised. The functional significance of EBA remains to be elucidated.en
dc.description.statementofresponsibilityJ G Lawrenson, Mounir N Ghabriel, A R Reid, T N Gajree, and G Allten
dc.language.isoenen
dc.publisherBMJ Publishing Groupen
dc.subjectEye; Orbit; Blood-Brain Barrier; Optic Nerve; Retina; Choroid; Ciliary Body; Iris; Animals; Rats; Rats, Sprague-Dawley; Antigens, Surface; Microscopy, Immunoelectron; Immunohistochemistry; Maleen
dc.titleDistribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the raten
dc.typeJournal articleen
dc.identifier.rmid0030006268en
dc.identifier.doi10.1136/bjo.79.5.462en
dc.identifier.pubid70274-
pubs.library.collectionAnatomical Sciences publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGhabriel, M. [0000-0002-9153-271X]en
Appears in Collections:Anatomical Sciences publications

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