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https://hdl.handle.net/2440/53534
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Type: | Journal article |
Title: | Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: Results from the DINO trial |
Author: | Smithers, L. Gibson, R. McPhee, A. Makrides, M. |
Citation: | Prostaglandins, Leukotrienes and Essential Fatty Acids, 2008; 79(3-5):141-146 |
Publisher: | Churchill Livingstone |
Issue Date: | 2008 |
ISSN: | 0952-3278 1532-2823 |
Statement of Responsibility: | L.G. Smithers, R.A. Gibson, A. McPhee and M. Makrides |
Abstract: | Formula supplemented with docosahexaenoic acid (DHA) improves retinal function of preterm infants but the optimal dose is unknown. In a randomized controlled trial we examined the effect of increasing the DHA concentration of human milk and formula on circulating fatty acids of preterm infants. Infants born <33 weeks gestation were fed high-DHA milk (1% total fat as DHA) or standard-DHA milk (0.2-0.3% DHA) until reaching their estimated due date (EDD). Milk arachidonic acid (AA) concentration was approximately 0.5% for both groups. At EDD, erythrocyte membrane phospholipid DHA was elevated in the high-DHA group compared with standard-DHA (mean+/-SD, high-DHA 6.8+/-1.2, standard-DHA 5.2+/-0.7, p<0.0005) but AA was lower (high-DHA 14.9+/-1.3, standard-DHA 16.0+/-1.2, p<0.0005). Feeding preterm infants human milk and formula with 1% DHA raises but does not saturate erythrocyte phospholipids with DHA. Milk exceeding 1% DHA may be required to increase DHA status to levels seen in term infants. |
Keywords: | Milk, Human Humans Body Weight Birth Weight Docosahexaenoic Acids Fatty Acids Body Height Double-Blind Method Infant Formula Infant, Newborn Infant, Premature Female Male |
Description: | Copyright © 2008 Elsevier Ltd All rights reserved. |
DOI: | 10.1016/j.plefa.2008.09.015 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623065/description#description |
Published version: | http://dx.doi.org/10.1016/j.plefa.2008.09.015 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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