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https://hdl.handle.net/2440/53538
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Type: | Journal article |
Title: | Symptoms and sleep patterns during inpatient treatment of methamphetamine withdrawal: A comparison of mirtazapine and modafinil with treatment as usual |
Author: | McGregor, C. Srisurapanont, M. Mitchell, A. Wickes, W. White, J. |
Citation: | Journal of Substance Abuse Treatment, 2008; 35(3):334-342 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2008 |
ISSN: | 0740-5472 1873-6483 |
Statement of Responsibility: | Catherine McGregor, Manit Srisurapanont, Amanda Mitchell, Wendy Wickes and Jason M. White |
Abstract: | The safety and tolerability of modafinil (400 mg/day, n = 14) and mirtazapine (60 mg/day, n = 13) in inpatient methamphetamine withdrawal treatment were compared to a historical comparison group receiving treatment as usual (pericyazine, 2.5-10 mg/day, n = 22). Modafinil and mirtazapine were well tolerated, producing minimal positive subjective effects and no discontinuation effects in this open-label study. Side effects were mild and transient. Aches and pains were most commonly reported by participants receiving mirtazapine, whereas headache was reported by modafinil-treated participants. Modafinil-treated participants had a milder withdrawal syndrome as measured by the Amphetamine Cessation Symptom Assessment and less sleep disturbance in comparison to mirtazapine. Pericyazine was associated with a more severe withdrawal syndrome in comparison to mirtazapine and modafinil. Both modafinil and mirtazapine were safe and well tolerated in methamphetamine withdrawal treatment. However, these early findings of efficacy in symptom amelioration should be replicated in an adequately powered, randomized, placebo-controlled double-blind design. |
Keywords: | Humans Amphetamine-Related Disorders Substance Withdrawal Syndrome Benzhydryl Compounds Mianserin Phenothiazines Central Nervous System Stimulants Antidepressive Agents, Tricyclic Severity of Illness Index Adult Middle Aged Inpatients Substance Abuse Treatment Centers Female Male Sleep Wake Disorders Modafinil Mirtazapine |
Description: | Copyright © 2008 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.jsat.2007.12.003 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/525475/description#description |
Published version: | http://dx.doi.org/10.1016/j.jsat.2007.12.003 |
Appears in Collections: | Aurora harvest 5 Pharmacology publications |
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