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https://hdl.handle.net/2440/53780
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Type: | Journal article |
Title: | Ovulation induction using low-dose step-up rFSH in Vietnamese women with polycystic ovary syndrome |
Author: | Lan, V. Norman, R. Nhu, G. Tuan, P. Tuong, H. |
Citation: | Reproductive Biomedicine Online, 2009; 18(4):516-521 |
Publisher: | Reproductive Healthcare Ltd. |
Issue Date: | 2009 |
ISSN: | 1472-6483 1472-6491 |
Statement of Responsibility: | V.T.N. Lan, R.J. Norman, G.H. Nhu, P.H. Tuan, H.M. Tuong |
Abstract: | The aim of this study was to assess the effectiveness and safety of a low-dose step-up protocol with a recombinant FSH starting dose of 25 IU for ovulation induction in anovulatory patients with polycystic ovary syndrome (PCOS) and a normal or low body mass index (BMI). In this prospective, non-comparative, open trial, 183 PCOS patients who had three unsuccessful cycles of ovulation induction with clomiphene citrate received recombinant FSH (Puregon((R))) 25 IU/day for 14 days, the dose was then increased by 25 IU every 5 days if there was no follicle of >12 mm diameter (maximum 150 IU/day). Human chorionic gonadotrophin was administered when the lead follicle was >/=18 mm, and intrauterine insemination was performed 36 h later. Duration of stimulation was 15.9 +/- 4.8 days and total FSH dose was 484 +/- 257 IU. A developing follicle was observed in 96.7% of cycles, of which 62.1% had unifollicular development and 15.8% were cancelled due to over-response. The clinical and ongoing pregnancy rates were 35.5% and 33.9%, respectively. There were no multiple pregnancies, and only one case of mild ovarian hyperstimulation syndrome. A low-dose step-up protocol with a recombinant FSH starting dose of 25 IU/day is effective and safe in anovulatory Vietnamese PCOS patients with a low or normal BMI. |
Keywords: | body mass index ovulation induction polycystic ovary syndrome pregnancy rate recombinant human FSH |
DOI: | 10.1016/S1472-6483(10)60128-9 |
Published version: | http://dx.doi.org/10.1016/s1472-6483(10)60128-9 |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
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