Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/53891
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Type: Journal article
Title: Pharmacotherapy of methamphetamine addiction: an update
Author: Elkashef, A.
Vocci, F.
Hanson, G.
White, J.
Wickes, W.
Tiihonen, J.
Citation: Substance Abuse, 2008; 29(3):31-49
Publisher: The Hawthorn Medical Press
Issue Date: 2008
ISSN: 0889-7077
1547-0164
Statement of
Responsibility: 
Ahmed Elkashef, Frank Vocci, Glen Hanson, Jason White, Wendy Wickes and Jari Tiihonen
Abstract: Abstract Methamphetamine dependence is a serious public health problem worldwide for which there are no approved pharmacological treatments. Psychotherapy is still the mainstay of treatment; however, relapse rates are high. The search for effective pharmacological treatment has intensified in the last decade. This review will highlight progress in pharmacological interventions to treat methamphetamine dependence as well as explore new pharmacological targets. Published data from clinical trials for stimulant addiction were searched using PubMed and summarized, as well as highlights from a recent symposium on methamphetamine pharmacotherapy presented at the ISAM 2006 meeting, including interim analysis data from an ongoing D-amphetamine study in Australia. Early pilot data are encouraging for administering D-amphetamine and methylphenidate as treatment for heavy amphetamine users. Abilify at 15 mg/day dose increased amphetamine use in an outpatient pilot study. Sertraline, ondansetron, baclofen, tyrosine, and imipramine were ineffective in proof-of-concept studies. Development of pharmacotherapy for methamphetamine dependence is still in an early stage. Data suggesting D-amphetamine and methylphenidate as effective pharmacotherapy for methamphetamine addiction will need to be confirmed by larger trials. Preclinical data suggest that use of GVG, CB1 antagonist, and lobeline are also promising therapeutic strategies.
Keywords: Methamphetamine; pharmacotherapy; bupropion; aripiprazole; methylphenidate; D-amphetamine
RMID: 0020084706
DOI: 10.1080/08897070802218554
Appears in Collections:Pharmacology publications

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