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https://hdl.handle.net/2440/54189
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dc.contributor.author | Ho, L. | - |
dc.contributor.author | Read, S. | - |
dc.contributor.author | Dorstyn, L. | - |
dc.contributor.author | Lambrusco, L. | - |
dc.contributor.author | Kumar, S. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Oncogene, 2008; 27(24):3393-3404 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.issn | 1476-5594 | - |
dc.identifier.uri | http://hdl.handle.net/2440/54189 | - |
dc.description.abstract | Caspase-2 is one of the most conserved caspases, yet its biological function remains a matter of controversy. In the present article we analysed mouse embryonic fibroblasts (MEFs) from caspase-2 knockout mice for their sensitivity to various apoptosis inducing agents. We found that cell death induced by drugs that disrupt cytoskeleton is significantly inhibited in Casp2- /- MEFs. These drugs included zoledronic acid, vincristine, cytochalasin D and paclitaxel. We demonstrate that MEFs lacking Casp2 show clonogenic survival following drug treatment, whereas all Casp2+/+ MEFs die, indicating that caspase-2 is required for apoptosis induced by cytoskeletal disruption. We further found that caspase-2 mediates apoptosis via Piddosome, Bid and Bax activation, and cytochrome c release. In the absence of caspase-2, Bid and Bax activation, and cytochrome c release are significantly delayed following drug treatment. Our data provide strong support for a context-dependent function of caspase-2 in apoptosis. | - |
dc.description.statementofresponsibility | L H Ho, S H Read, L Dorstyn, L Lambrusco and S Kumar. | - |
dc.language.iso | en | - |
dc.publisher | Nature Publishing Group | - |
dc.source.uri | http://dx.doi.org/10.1038/sj.onc.1211005 | - |
dc.subject | apoptosis | - |
dc.subject | caspase-2 activation | - |
dc.subject | Bid | - |
dc.subject | Bax | - |
dc.subject | initiator caspase | - |
dc.subject | cytoskeleton | - |
dc.title | Capase-2 is required for cell death induced by cytoskeletal disruption | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/sj.onc.1211005 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Kumar, S. [0000-0001-7126-9814] | - |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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