Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/54911
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dc.contributor.authorReuter, S.en
dc.contributor.authorFaull, R.en
dc.contributor.authorRanieri, E.en
dc.contributor.authorEvans, A.en
dc.date.issued2009en
dc.identifier.citationNephrology Dialysis Transplantation, 2009; 24(3):990-996en
dc.identifier.issn0931-0509en
dc.identifier.issn1460-2385en
dc.identifier.urihttp://hdl.handle.net/2440/54911-
dc.description.abstractBackground. Anaemia is a common complication associated with haemodialysis and is usually managed by treatment with recombinant human erythropoietin (rHuEPO). However, many patients remain hyporesponsive to rHuEPO treatment despite adequate iron therapy. The effect of L-carnitine administration on rHuEPO dose and/or haematocrit in haemodialysis patients has been previously reported with equivocal results. This study examined the relationship between endogenous carnitine pool composition and rHuEPO requirements in long-term haemodialysis patients. Methods. Pre-dialysis blood samples were collected from 87 patients and analysed for plasma L-carnitine and individual acylcarnitine levels by LCMS/MS. As an indication of rHuEPO responsiveness, erythropoietin resistance index (ERI) was calculated as rHuEPO dose/kg/week normalized for haemoglobin levels. Results. A significant negative correlation between L-carnitine levels and ERI was found (P = 0.0421). All patients categorized as high ERI (>0.02 µg/kg/week/gHb) exhibited subnormal L-carnitine levels (<30 µM); conversely, patients with normal L-carnitine levels (>30 µM) displayed low ERI values (<0.02 µg/kg/week/gHb). More importantly, the ratio of non-acetyl acylcarnitines/total carnitine was significantly positively correlated with ERI (P = 0.0062). Conclusions. These data illustrate the relationship between carnitine levels and response to rHuEPO treatment in haemodialysis patients, in particular, the importance of the proportion of long-chain acylcarnitines within the plasma carnitine pool. This proportion may be more indicative of the response to L-carnitine supplementation than absolute L-carnitine levels alone.en
dc.description.statementofresponsibilityStephanie E. Reuter, Randall J. Faull, Enzo Ranieri and Allan M. Evansen
dc.language.isoenen
dc.publisherOxford Univ Pressen
dc.subjectacylcarnitine; anaemia; erythropoietin; haemodialysis; L-carnitineen
dc.titleEndogenous plasma carnitine pool composition and response to erythropoietin treatment in chronic haemodialysis patientsen
dc.typeJournal articleen
dc.identifier.rmid0020090219en
dc.identifier.doi10.1093/ndt/gfn588en
dc.identifier.pubid39274-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Medicine publications

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