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Type: Journal article
Title: Optical tweezers for single cells
Author: Zhang, H.
Liu, K.
Citation: Journal of the Royal Society. Interface, 2008; 5(24):671-690
Publisher: The Royal Society Publishing
Issue Date: 2008
ISSN: 1742-5689
Statement of
Hu Zhang and Kuo-Kang Liu
Abstract: Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include non-contact force for cell manipulation, force resolution as accurate as 100 aN and amiability to liquid medium environments. Their wide range of applications, such as transporting foreign materials into single cells, delivering cells to specific locations and sorting cells in microfluidic systems, are reviewed in this article. Recent developments of OT for nanomechanical characterization of various biological cells are discussed in terms of both their theoretical and experimental advancements. The future trends of employing OT in single cells, especially in stem cell delivery, tissue engineering and regenerative medicine, are prospected. More importantly, current limitations and future challenges of OT for these new paradigms are also highlighted in this review.
Keywords: optical tweezers; micromanipulation; microfluidic devices; cell sorting; cellular biomechanics; tissue engineering
RMID: 0020093477
DOI: 10.1098/rsif.2008.0052
Appears in Collections:Chemical Engineering publications

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