Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5535
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Type: Journal article
Title: Apoptosis in liver damage produced by tunicamycin
Author: Finnie, J.
Read, S.
Swift, J.
Citation: Australian Veterinary Journal, 2004; 82(1-2):87-90
Publisher: Australian Veterinary Assn
Issue Date: 2004
ISSN: 0005-0423
1751-0813
Abstract: OBJECTIVE:To determine whether apoptosis contributes to hepatocyte loss in tunicamycin poisoning. DESIGN:Groups of four guinea pigs were given 400 microg/kg of tunicamycin subcutaneously and killed at 24 h intervals up to 72 h post-injection. Livers were examined by routine histological methods and ancillary techniques (TUNEL staining, endonuclease activation, caspase activity, and electron microscopy) to ascertain whether any hepatocyte injury was apoptotic. RESULTS:Many hepatocytes exposed to tunicamycin showed evidence of apoptosis in the form of nuclear karyorrhexis with chromatin margination and crescent formation, TUNEL-positivity, DNA laddering, elevated caspase activity and apoptotic body formation. CONCLUSION:Tunicamycin caused the death of many hepatocytes in the livers of guinea pigs by apoptosis.
Keywords: Liver; Animals; Animals, Domestic; Guinea Pigs; Plant Poisoning; Tunicamycin; Injections, Subcutaneous; In Situ Nick-End Labeling; Apoptosis; Animal Feed
RMID: 0020040181
DOI: 10.1111/j.1751-0813.2004.tb14652.x
Appears in Collections:Pathology publications

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