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|Title:||Antisense suppression of collagen VI synthesis results in reduced expression of collagen I in normal human osteoblast-like cells|
|Citation:||Bioscience Biotechnology and Biochemistry, 2002; 66(12):2743-2747|
|Publisher:||Japan Soc Biosci Biotechn Agrochem|
|Satoru Harumiya, Mark A. Gibson, and Yasuko Koshihara|
|Abstract:||A transient increase in collagen VI expression precedes the accumulation of collagen I associated with interleukin-4 (IL-4)-induced mineralization in human osteoblast-like cells. Transfection with an antisense oligonucleotide specific for α1(VI) collagen mRNA was shown to attenuate mRNA levels of collagens VI and I. Incubating IL-4 treated cells with anti-collagen VI antiserum decreased expression of α1(I) mRNA. The results suggest that collagen VI may regulate collagen I expression in the early phase of IL-4-induced mineralization.|
|Keywords:||osteoblast; collagen VI; collagen I; human; antisense oligonucleotide|
|Description:||Copyright (c) 2003 by Japan Society for Bioscience, Biotechnology, and Agrochemistry|
|Appears in Collections:||Pathology publications|
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