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Type: Journal article
Title: Antisense suppression of collagen VI synthesis results in reduced expression of collagen I in normal human osteoblast-like cells
Author: Harumiya, S.
Gibson, M.
Koshihara, Y.
Citation: Bioscience Biotechnology and Biochemistry, 2002; 66(12):2743-2747
Publisher: Japan Soc Biosci Biotechn Agrochem
Issue Date: 2002
ISSN: 0916-8451
Statement of
Satoru Harumiya, Mark A. Gibson, and Yasuko Koshihara
Abstract: A transient increase in collagen VI expression precedes the accumulation of collagen I associated with interleukin-4 (IL-4)-induced mineralization in human osteoblast-like cells. Transfection with an antisense oligonucleotide specific for α1(VI) collagen mRNA was shown to attenuate mRNA levels of collagens VI and I. Incubating IL-4 treated cells with anti-collagen VI antiserum decreased expression of α1(I) mRNA. The results suggest that collagen VI may regulate collagen I expression in the early phase of IL-4-induced mineralization.
Keywords: osteoblast; collagen VI; collagen I; human; antisense oligonucleotide
Description: Copyright (c) 2003 by Japan Society for Bioscience, Biotechnology, and Agrochemistry
RMID: 0020022058
DOI: 10.1271/bbb.66.2743
Appears in Collections:Pathology publications

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