Adelaide Research & Scholarship
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https://hdl.handle.net/2440/55854
| Type: | Journal article |
| Title: | Synthesis of N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives |
| Author: | Hai, L. Linyan Wu, L. Huang, J. Cheng, L. Wu, Y. |
| Citation: | Journal of Sichuan University (Medical Science Edition), 2004; 35(4):552-554 |
| Publisher: | Huaxi Yike Daxue |
| Issue Date: | 2004 |
| ISSN: | 1672-173X |
| Statement of Responsibility: | Hai, L; Wu, LY; Huang, J; Cheng, L. and Wu, Y. |
| Abstract: | OBJECTIVE: To synthesize N1-(aryl)alkyloxyacyl-5-fluorouracil derivatives and investigate their antitumor activities. METHODS: Title compounds (I) were prepared by 5-fluorouracil which was trimethylsilylated by hexamethyl-di-silazane, and then acylated. Hydrogenization of compounds (I) brought on compounds (II), which were esterified to produce title compounds (III) afterwards. RESULTS: Twelve title compounds were synthesized. CONCLUSION: These compounds were designed products confirmed by 1H-NMR, IR and MS spectral data. |
| Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/15291126 |
| Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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