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Type: Journal article
Title: Effects of electro-acupuncture on the expression of c-jun and c-fos in spared dorsal root ganglion and associated spinal laminae following removal of adjacent dorsal root ganglia in cats
Author: Wang, T.
Yuan, W.
Ke, Q.
Song, X.
Zhou, X.
Kang, Y.
Zhang, H.
Lin, Y.
Hu, Y.
Feng, Z.
Linyan Wu, L.
Zhou, X.
Citation: Neuroscience, 2006; 140(4):1169-1176
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2006
ISSN: 0306-4522
Statement of
T.T.-H. Wang, W.-L. Yuan, Q. Ke, X.-B. Song, X. Zhou, Y. Kang, H.-T. Zhang, Y. Lin, Y.-L. Hu, Z.-T. Feng, L.L.-Y. Wu and X.-F. Zhou
Abstract: This study evaluated the plastic changes of c-jun and c-fos in the right sixth lumbar dorsal root ganglion (L₆ DRG), Rexed’s lamina II in representative spinal segments L₃, L₅, and L₆ and in the nucleus dorsalis (ND) at L₃segments after electro-acupuncture (EA) in cats subjected to removal of L₁–L₅ and L₇–S₂DRG. Following dorsal root ganglionectomy, there was a significant increase in the density of c-jun immunoreactivity in the neurons and glia in spinal lamina II and in the ND; there was also marked elevation in the expression of c-fos in ND. In both cases there was no change in the c-jun and c-fos immunoreactivity in the DRG. After EA in the operated animals, there was an up-regulation in the expression of c-jun in the L₆ DRG and the associated spinal lamina II; however, increased c-fos expression was detected only in the L₆ DRG. Western blot and RT-PCR were also performed to quantitatively explore the mRNA and protein expression changes in the spinal dorsal horn and associated DRG. Following partial deafferentation, there was a significant increase in the protein level of both c-jun and c-fos in the dorsal horn, while, in both cases there was no change in c-jun and c-fos protein and mRNA in the DRG. After EA in the operated animals, both c-jun protein and its mRNA in the L₆ DRG as well as the associated dorsal horn of L₆ spinal segment were upregulated, but increased c-fos protein and its mRNA was observed only in the L₆ DRG. These findings suggested that c-jun and c-fos might be related to the acupuncture promoted spinal cord plasticity as reported previously.
Keywords: electro-acupuncture; c-jun; c-fos; dorsal root ganglion; lamina II; nucleus dorsalis
RMID: 0020094243
DOI: 10.1016/j.neuroscience.2006.03.008
Appears in Collections:Obstetrics and Gynaecology publications

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