Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/56203
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Metabolic and behavioral compensations in response to caloric restriction: Implications for the maintenance of weight loss |
Author: | Redman, L. Heilbronn, L. Martin, C. de Jonge, L. Williamson, D. DeLany, J. Ravussin, E. |
Citation: | PLoS One, 2009; 4(2):1-9 |
Publisher: | Public Library of Science |
Issue Date: | 2009 |
ISSN: | 1932-6203 1932-6203 |
Editor: | Wang, C. |
Statement of Responsibility: | Leanne M. Redman, Leonie K. Heilbronn, Corby K. Martin, Lilian de Jonge, Donald A. Williamson, James P. Delany, Eric Ravussin, for the Pennington CALERIE team |
Abstract: | <h4>Background</h4>Metabolic and behavioral adaptations to caloric restriction (CR) in free-living conditions have not yet been objectively measured.<h4>Methodology and principal findings</h4>Forty-eight (36.8+/-1.0 y), overweight (BMI 27.8+/-0.7 kg/m(2)) participants were randomized to four groups for 6-months;<h4>Control</h4>energy intake at 100% of energy requirements; CR: 25% calorie restriction; CR+EX: 12.5% CR plus 12.5% increase in energy expenditure by structured exercise; LCD: low calorie diet (890 kcal/d) until 15% weight reduction followed by weight maintenance. Body composition (DXA) and total daily energy expenditure (TDEE) over 14-days by doubly labeled water (DLW) and activity related energy activity (AREE) were measured after 3 (M3) and 6 (M6) months of intervention. Weight changes at M6 were -1.0+/-1.1% (CONTROL), -10.4+/-0.9% (CR), -10.0+/-0.8% (CR+EX) and -13.9+/-0.8% (LCD). At M3, absolute TDEE was significantly reduced in CR (-454+/-76 kcal/d) and LCD (-633+/-66 kcal/d) but not in CR+EX or controls. At M6 the reduction in TDEE remained lower than baseline in CR (-316+/-118 kcal/d) and LCD (-389+/-124 kcal/d) but reached significance only when CR and LCD were combined (-351+/-83 kcal/d). In response to caloric restriction (CR/LCD combined), TDEE adjusted for body composition, was significantly lower by -431+/-51 and -240+/-83 kcal/d at M3 and M6, respectively, indicating a metabolic adaptation. Likewise, physical activity (TDEE adjusted for sleeping metabolic rate) was significantly reduced from baseline at both time points. For control and CR+EX, adjusted TDEE (body composition or sleeping metabolic rate) was not changed at either M3 or M6.<h4>Conclusions</h4>For the first time we show that in free-living conditions, CR results in a metabolic adaptation and a behavioral adaptation with decreased physical activity levels. These data also suggest potential mechanisms by which CR causes large inter-individual variability in the rates of weight loss and how exercise may influence weight loss and weight loss maintenance.<h4>Trial registration</h4>ClinicalTrials.gov NCT00099151. |
Keywords: | Pennington CALERIE Team Humans Weight Loss Body Mass Index Behavior Control Caloric Restriction Body Composition Energy Metabolism Energy Intake Adult Middle Aged Female Male |
Rights: | Copyright: © 2009 Redman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
DOI: | 10.1371/journal.pone.0004377 |
Published version: | http://dx.doi.org/10.1371/journal.pone.0004377 |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hdl_56203.pdf | Published version | 360.35 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.