Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5626
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Type: Journal article
Title: Recent advances in the development of multifactorial therapies for the treatment of traumatic brain injury
Author: Vink, R.
Van Den Heuvel, C.
Citation: Expert Opinion on Investigational Drugs, 2004; 13(10):1263-1274
Publisher: Ashley Publications Ltd
Issue Date: 2004
ISSN: 1354-3784
1744-7658
Statement of
Responsibility: 
Robert Vink and Corinna Van Den Heuvel
Abstract: Traumatic brain injury (TBI) is one of the leading causes of death and disability in the industrialised world and remains a major health problem with serious socioeconomic consequences. So far, despite encouraging preclinical results, almost all neuroprotection trials have failed to show any significant efficacy in the treatment of clinical TBI. This may be due, in part, to the fact that most of the therapies investigated have targeted an individual injury factor. It is now recognised that TBI is a very heterogeneous type of injury that varies widely in its aetiology, clinical presentation, severity and pathophysiology. The pathophysiological sequelae of TBI are mediated by an interaction of acute and delayed molecular, biochemical and physiological events that are both complex and multifaceted. Accordingly, a successful TBI treatment may have to simultaneously attenuate many injury factors. Recent efforts in experimental TBI have, therefore, focused on the development of neuropharmacotherapies that target multiple injury factors and thus improve the likelihood of a successful outcome. This review will focus on three such novel compounds that are currently being assessed in clinical trials; progesterone, dexanabinol and dexamethasone, and provide an update on the progress of both magnesium and cyclosporin A.
Keywords: Mitochondria; Animals; Humans; Brain Injuries; Magnesium; Cyclosporine; Dexamethasone; Progesterone; Neuroprotective Agents; Oxidative Stress; Dronabinol
Description: Copyright © 2004 Ashley Publications
RMID: 0020041263
DOI: 10.1517/13543784.13.10.1263
Appears in Collections:Pathology publications

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