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https://hdl.handle.net/2440/5643
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Type: | Journal article |
Title: | Effects of Prostaglandin E1 analogue, Misoprostol, on the development of adjuvant arthritis in rats |
Author: | Rainsford, K. Whitehouse, M. Vernon-Roberts, B. |
Citation: | Inflammopharmacology: experimental and clinical studies, 1995; 3(1):49-63 |
Publisher: | Kluwer Academic Publishers |
Issue Date: | 1995 |
ISSN: | 0925-4692 1568-5608 |
Statement of Responsibility: | K. D. Rainsford, M. W. Whitehouse and B. Vernon-Roberts |
Abstract: | Prostaglandins (PG) E , E and the PGE analogue, misoprostol, have been shown to inhibit T-cell functions and the production by activated monocytes or macrophages of interleukin-1, indicating that these PGs may have potential anti-arthritic activity by suppressing T-cell and monocyte activity. In view of this the potential anti-arthritic effects of the long half-life PG, misoprostol (MPL), were examined in adjuvant arthritic rats under prophylactic and therapeutic treatment regimes. Transcutaneous or subcutaneous MPL given at 200 Μg/kg/day but not at 50 or 5 Μg/kg/day when given 0 to +5 or 0 to + 14 days post-induction inhibited the development of the disease whereas the orally administered drug was without effects. MPL given transcutaneously with oral indomethacin (1 or 2 mg/kg/day) on days +17 to + 30 post-induction produced greater anti-inflammatory effects than with this NSAID alone. MPL given orally in combination with this NSAID did not enhance the anti-inflammatory effects of the latter. MPL 200 Μg/kg given transcutaneously exhibited anti-ulcer activity against indomethacin (30 mg/kg p.o.), naproxen (10 mg/kg i.p.) or piroxicam (5 mg/kg i.p.) induced gastric damage in arthritic rats and this was comparable with that from 100 Μg/kg MPL given orally. These results show that MPL has both unique anti-arthritic effects only when given transcutaneously or parenterally as well as anti-ulcer activity. |
Keywords: | Prostaglandin analogues Arthritis Non-steroidal anti-inflammatory drugs Misoprostol Inflammation |
DOI: | 10.1007/BF02659110 |
Published version: | http://dx.doi.org/10.1007/bf02659110 |
Appears in Collections: | Aurora harvest 5 Pathology publications |
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