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https://hdl.handle.net/2440/5643
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dc.contributor.author | Rainsford, K. | - |
dc.contributor.author | Whitehouse, M. | - |
dc.contributor.author | Vernon-Roberts, B. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Inflammopharmacology: experimental and clinical studies, 1995; 3(1):49-63 | - |
dc.identifier.issn | 0925-4692 | - |
dc.identifier.issn | 1568-5608 | - |
dc.identifier.uri | http://hdl.handle.net/2440/5643 | - |
dc.description.abstract | Prostaglandins (PG) E , E and the PGE analogue, misoprostol, have been shown to inhibit T-cell functions and the production by activated monocytes or macrophages of interleukin-1, indicating that these PGs may have potential anti-arthritic activity by suppressing T-cell and monocyte activity. In view of this the potential anti-arthritic effects of the long half-life PG, misoprostol (MPL), were examined in adjuvant arthritic rats under prophylactic and therapeutic treatment regimes. Transcutaneous or subcutaneous MPL given at 200 Μg/kg/day but not at 50 or 5 Μg/kg/day when given 0 to +5 or 0 to + 14 days post-induction inhibited the development of the disease whereas the orally administered drug was without effects. MPL given transcutaneously with oral indomethacin (1 or 2 mg/kg/day) on days +17 to + 30 post-induction produced greater anti-inflammatory effects than with this NSAID alone. MPL given orally in combination with this NSAID did not enhance the anti-inflammatory effects of the latter. MPL 200 Μg/kg given transcutaneously exhibited anti-ulcer activity against indomethacin (30 mg/kg p.o.), naproxen (10 mg/kg i.p.) or piroxicam (5 mg/kg i.p.) induced gastric damage in arthritic rats and this was comparable with that from 100 Μg/kg MPL given orally. These results show that MPL has both unique anti-arthritic effects only when given transcutaneously or parenterally as well as anti-ulcer activity. | - |
dc.description.statementofresponsibility | K. D. Rainsford, M. W. Whitehouse and B. Vernon-Roberts | - |
dc.language.iso | en | - |
dc.publisher | Kluwer Academic Publishers | - |
dc.source.uri | http://dx.doi.org/10.1007/bf02659110 | - |
dc.subject | Prostaglandin analogues | - |
dc.subject | Arthritis | - |
dc.subject | Non-steroidal anti-inflammatory drugs | - |
dc.subject | Misoprostol | - |
dc.subject | Inflammation | - |
dc.title | Effects of Prostaglandin E1 analogue, Misoprostol, on the development of adjuvant arthritis in rats | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/BF02659110 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Pathology publications |
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