Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5667
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dc.contributor.authorHaynes, D.en
dc.contributor.authorCrotti, T.en
dc.contributor.authorHaywood, M.en
dc.date.issued2000en
dc.identifier.citationJournal of Biomedical Materials Research. Part B: Applied Biomaterials, 2000; 49(2):167-175en
dc.identifier.issn1552-4973en
dc.identifier.issn0021-9304en
dc.identifier.urihttp://hdl.handle.net/2440/5667-
dc.description.abstractThe biological response to prosthetic wear particles is thought to stimulate the bone loss that often leads to prosthetic joint failure. This in vitro study investigates how metal particles corrode under physiological conditions and how biological responses to particles may change as particles age. Cobalt chrome alloy (CoCr) and 316L stainless steel (SS) particles of a similar size, shape, and concentration to those found in revision tissues were used. The release of soluble metal (Co and Cr from CoCr particles and Fe from 316L SS) was markedly reduced with time under physiological conditions. CoCr particles released far more Co than Cr. The biological responses to aged and freshly produced particles were tested using human monocytes because wear particles are usually associated with this type of cell in the periarticular tissues. Aged particles of both metals were markedly less toxic to monocytes than freshly produced particles. Aged particles also appeared to stimulate the release of more IL-6 and prostaglandin E(2) from monocytes. The results show that CoCr and 316L SS particles become less toxic but may induce more bone resorbing mediators as they age in vivo.en
dc.language.isoenen
dc.publisherJohn Wiley & Sons Incen
dc.subjectMonocytes; Cells, Cultured; Humans; Chromium Alloys; Cobalt; Iron; Biocompatible Materials; Time Factorsen
dc.titleCorrosion of and changes in biological effects of cobalt chrome alloy and 316L staianless steel prosthetic particles with ageen
dc.typeJournal articleen
dc.identifier.rmid0001000801en
dc.identifier.doi10.1002/(SICI)1097-4636(200002)49:2<167::AID-JBM3>3.0.CO;2-9en
dc.identifier.pubid63575-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidCrotti, T. [0000-0002-5422-3758]en
Appears in Collections:Pathology publications

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