Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
Full metadata record
|dc.identifier.citation||Journal of Biomedical Materials Research. Part B: Applied Biomaterials, 2000; 49(2):167-175||en|
|dc.description.abstract||The biological response to prosthetic wear particles is thought to stimulate the bone loss that often leads to prosthetic joint failure. This in vitro study investigates how metal particles corrode under physiological conditions and how biological responses to particles may change as particles age. Cobalt chrome alloy (CoCr) and 316L stainless steel (SS) particles of a similar size, shape, and concentration to those found in revision tissues were used. The release of soluble metal (Co and Cr from CoCr particles and Fe from 316L SS) was markedly reduced with time under physiological conditions. CoCr particles released far more Co than Cr. The biological responses to aged and freshly produced particles were tested using human monocytes because wear particles are usually associated with this type of cell in the periarticular tissues. Aged particles of both metals were markedly less toxic to monocytes than freshly produced particles. Aged particles also appeared to stimulate the release of more IL-6 and prostaglandin E(2) from monocytes. The results show that CoCr and 316L SS particles become less toxic but may induce more bone resorbing mediators as they age in vivo.||en|
|dc.publisher||John Wiley & Sons Inc||en|
|dc.subject||Monocytes; Cells, Cultured; Humans; Chromium Alloys; Cobalt; Iron; Biocompatible Materials; Time Factors||en|
|dc.title||Corrosion of and changes in biological effects of cobalt chrome alloy and 316L staianless steel prosthetic particles with age||en|
|dc.identifier.orcid||Crotti, T. [0000-0002-5422-3758]||en|
|Appears in Collections:||Pathology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.