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https://hdl.handle.net/2440/56795
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Type: | Journal article |
Title: | Aortic intima media thickness is an early marker of atherosclerosis in children with type 1 diabetes mellitus |
Author: | Harrington, J. Pena Vargas, A. Gent, R. Hirte, C. Couper, J. |
Citation: | Journal of Pediatrics, 2010; 156(2):237-241 |
Publisher: | Mosby Inc |
Issue Date: | 2010 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Jennifer Harrington, Alexia S. Peña, Roger Gent, Craig Hirte and Jennifer Couper |
Abstract: | <h4>Objective</h4>To compare aortic intima media thickness (aIMT) to carotid intima media thickness (cIMT) as a marker of early atherosclerosis in children with type 1 diabetes mellitus and to examine the associations of aIMT to known cardiovascular risk factors.<h4>Study design</h4>66 children with type 1 diabetes mellitus (age, 14.1 +/- 2.5 years; 37 male) and 32 healthy control subjects (age, 14.2 +/- 3 years; 15 male) underwent assessment of vascular structure (cIMT and aIMT) and vascular function (flow mediated dilatation [FMD] and glyceryl trinitrate induced dilatation [GTN]). Fasting blood tests were taken to measure levels of hemoglobin A1c, high sensitive C reactive protein, total homocyst(e)ine, serum folate, red cell folate, and lipids.<h4>Results</h4>aIMT, but not cIMT, was significantly greater in the children with type 1 diabetes mellitus than in control subjects (P < .001). In children with type 1 diabetes mellitus, aIMT correlated with glycosylated hemoglobin (r = 0.31, P = .01) and was independently associated with age (beta = 0.38, P = .001) and low-density lipoprotein cholesterol level (beta = 0.38, P = .001). Vascular function (GTN) was worse in children with type 1 diabetes mellitus who had an aIMT >95th percentile, as defined with the control subjects.<h4>Conclusions</h4>aIMT is an earlier marker than cIMT of preclinical atherosclerosis in children with type 1 diabetes mellitus and relates to known cardiovascular risk factors and metabolic control. |
Keywords: | Aorta, Abdominal Carotid Artery, Common Tunica Intima Humans Diabetes Mellitus, Type 1 Ultrasonography Early Diagnosis Multivariate Analysis Matched-Pair Analysis Linear Models Risk Factors Case-Control Studies Age Factors Adolescent Child Female Male Atherosclerosis Cholesterol, LDL Biomarkers Glycated Hemoglobin |
Description: | Crown copyright © 2010 Published by Mosby, Inc. |
DOI: | 10.1016/j.jpeds.2009.08.036 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/519245 |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2009.08.036 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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