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Type: Journal article
Title: Why do phage play dice?
Author: Avlund, M.
Dodd, I.
Semsey, S.
Sneppen, K.
Krishna, S.
Citation: Journal of Virology, 2009; 83(22):11416-11420
Publisher: Amer Soc Microbiology
Issue Date: 2009
ISSN: 0022-538X
Statement of
Mikkel Avlund, Ian B. Dodd, Szabolcs Semsey, Kim Sneppen, and Sandeep Krishna
Abstract: Phage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.
Keywords: Bacteriophage lambda; Probability; Stochastic Processes; Lysogeny; Virus Activation; Game Theory
Description: Copyright © 2009, American Society for Microbiology. All Rights Reserved.
RMID: 0020093082
DOI: 10.1128/JVI.01057-09
Appears in Collections:Biochemistry publications

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