Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5690
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dc.contributor.authorFinnie, J.en
dc.contributor.authorLewis, S.en
dc.contributor.authorManavis, J.en
dc.contributor.authorBlumbergs, P.en
dc.contributor.authorVan Den Heuvel, C.en
dc.contributor.authorJones, N.en
dc.date.issued1999en
dc.identifier.citationJournal of Clinical Neuroscience, 1999; 6(1):38-42en
dc.identifier.issn0967-5868en
dc.identifier.issn1532-2653en
dc.identifier.urihttp://hdl.handle.net/2440/5690-
dc.description.abstractAxonal injury (AI), an important determinant of clinical outcome after traumatic head injury in adults, has been little studied in child neurotrauma. In this experimental model, 10 anaesthetised, ventilated and physiologically monitored 4-5 week old lambs sustained a temporal impact to an unconstrained head. Examination of the brain 2 hours post-impact using amyloid precursor protein immunostaining, a sensitive marker of axonal damage, revealed widespread multifocal AI in the ipsilateral and contralateral hemispheres, brain stem and cerebellum in all cases. Impact contusions (predominantly microscopic) (8 10 ), contralateral contusions (2 10 ), parenchymal haemorrhage (10 10 ) and focal subarachnoid haemorrhage (10 10 ) were also present. Unusual multifocal cerebellar granular layer necrosis occurred in all impacted lambs. The pattern of AI in these lamb brains 2 hours post-impact was similar to that found in adult sheep using the same experimental paradigm.en
dc.description.statementofresponsibilityJ. Finnie, S. Lewis, Manavis, P. Blumbergs, C. Van Den Heuvel, N. Jonesen
dc.language.isoenen
dc.publisherCHURCHILL LIVINGSTONEen
dc.titleTraumatic axonal injury in lambs: a model for paediatric axonal damageen
dc.typeJournal articleen
dc.identifier.rmid0030006171en
dc.identifier.doi10.1016/S0967-5868(99)90601-Xen
dc.identifier.pubid70177-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidVan Den Heuvel, C. [0000-0001-7264-4655]en
Appears in Collections:Pathology publications

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