Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/56923
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Type: Journal article
Title: Effects of formalin fixing on the terahertz properties of biological tissues
Author: Sun, Y.
Fischer, B.
Pickwell-MacPherson, E.
Citation: Journal of Biomedical Optics, 2009; 14(6):064017-1-064017-7
Publisher: SPIE-Int Society Optical Engineering
Issue Date: 2009
ISSN: 1083-3668
1560-2281
Statement of
Responsibility: 
Yiwen Sun, Bernd M. Fischer and Emma Pickwell-MacPherson
Abstract: We demonstrate how the terahertz properties of porcine adipose tissue and skeletal muscle are affected by formalin fixing. Terahertz radiation is sensitive to covalently cross-linked proteins and can be used to probe unique spectroscopic signatures. We study in detail the changes arising from different fixation times and see that formalin fixing reduces the refractive index and the absorption coefficient of the samples in the terahertz regime. These fundamental properties affect the time-domain terahertz response of the samples and determine the level of image contrast that can be achieved.
Keywords: absorption coefficients; bio-optics; muscle; proteins; refractive index; terahertz spectroscopy; terahertz wave imaging
RMID: 0020094927
DOI: 10.1117/1.3268439
Appears in Collections:Electrical and Electronic Engineering publications

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