Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5702
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dc.contributor.authorFinnie, J.en
dc.contributor.authorVan Den Heuvel, C.en
dc.contributor.authorGebski, V.en
dc.contributor.authorManavis, J.en
dc.contributor.authorSummersides, G.en
dc.contributor.authorBlumbergs, P.en
dc.date.issued2001en
dc.identifier.citationJournal of Comparative Pathology, 2001; 124(02-Mar):159-164en
dc.identifier.issn0021-9975en
dc.identifier.issn1532-3129en
dc.identifier.urihttp://hdl.handle.net/2440/5702-
dc.descriptionCopyright © 2001 Harcourt Publishers Ltd. All rights reserved.en
dc.description.abstractThe heads of anaesthetized lambs aged 4-5 weeks were subjected to impact (temporal, frontal or occipital) of constant strength with a humane stunner. Two hours later, the brains were perfusion-fixed with 4% paraformaldehyde and serial whole coronal slices processed by routine methods. Sections were stained with haematoxylin and eosin or labelled with a monoclonal antibody to amyloid precursor protein, a sensitive marker of axonal injury and neuronal reaction. Microscopical evaluation of axonal, neuronal and vascular damage was performed with a quantitative grid system. Frontal impact produced the greatest damage, followed by occipital then temporal impact. An unusual lesion found in the majority of lambs subjected to impact was multifocal necrosis of the cerebellar granular layer. The findings should assist clinicians in evaluating the probable outcome of traumatic head injury in domestic animals.en
dc.description.statementofresponsibilityJ. W. Finnie, C. Van den Heuvel, V. Gebski, J. Manavis, G. E. Summersides and P. C. Blumbergsen
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623050/description#descriptionen
dc.language.isoenen
dc.publisherAcademic Press Ltden
dc.subjectFrontal Bone; Occipital Bone; Temporal Bone; Brain; Cerebellum; Neurons; Axons; Animals; Sheep; Brain Injuries; Head Injuries, Closed; Skull Fractures; Sheep Diseases; Amyloid beta-Protein Precursor; Biological Markers; Models, Animalen
dc.titleInvestigation of the effects of impacts to different regions of the lamb headen
dc.typeJournal articleen
dc.identifier.rmid0020010978en
dc.identifier.doi10.1053/jcpa.2000.0446en
dc.identifier.pubid61667-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidVan Den Heuvel, C. [0000-0001-7264-4655]en
Appears in Collections:Pathology publications

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