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Type: Journal article
Title: Chemotherapy-induced modifications to gastrointestinal microflora: Evidence and implications of change
Author: Stringer, A.
Gibson, R.
Bowen, J.
Keefe, D.
Citation: Current Drug Metabolism, 2009; 10(1):79-83
Publisher: Bentham Science Publishers Ltd.
Issue Date: 2009
ISSN: 1389-2002
Statement of
Andrea M. Stringer, Rachel J. Gibson, Joanne M. Bowen and Dorothy M.K. Keefe
Abstract: Mucositis is a common side effect of chemotherapy which remains poorly understood. Despite advances in the understanding of oral and small intestinal mucositis over recent years, large intestinal mucositis, including diarrhoea, has not been well defined and the underlying mechanisms of the condition are yet to be established. The majority of the literature available concerning large intestinal mucositis is based on clinical observations, with very little basic research existing. However, from the little research conducted, it is likely that the intestinal microflora play a role in the development of chemotherapy-induced mucositis. This review will explore the potentially important relationship between intestinal microflora and the subsequent development of chemotherapy-induced mucositis.
Keywords: Gastrointestinal Tract; Intestinal Mucosa; Intestine, Large; Animals; Humans; Diarrhea; Antineoplastic Agents; Mucositis
Description: © 2009 Bentham Science Publishers Ltd.
RMID: 0020090179
DOI: 10.2174/138920009787048419
Appears in Collections:Medicine publications

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