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https://hdl.handle.net/2440/57492
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Type: | Journal article |
Title: | Placental cytokine expression covaries with maternal asthma severity and fetal sex |
Author: | Scott, N. Hodyl, N. Murphy, V. Osei-Kumah, A. Wyper, H. Hodgson, D. Smith, R. Clifton, V. |
Citation: | Journal of Immunology, 2009; 182(3):1411-1420 |
Publisher: | American Association of Immunologists |
Issue Date: | 2009 |
ISSN: | 0022-1767 1550-6606 |
Statement of Responsibility: | Naomi M. Scott, Nicolette A. Hodyl, Vanessa E. Murphy, Annette Osei-Kumah, Hayley Wyper, Deborah M. Hodgson, Roger Smith and Vicki L. Clifton |
Abstract: | In the presence of maternal asthma, we have previously reported reduced placental blood flow, decreased cortisol metabolism, and reductions in fetal growth in response to maternal asthma and asthma exacerbations. We have proposed that these changes in placental function and fetal development may be related to activation of proinflammatory pathways in the placenta in response to maternal asthma. In the present study, we examined the influence of maternal asthma severity, inhaled glucocorticoid treatment, maternal cigarette use, placental macrophage numbers, and fetal sex on placental cytokine mRNA expression from a prospective cohort study of pregnant women with and without asthma. Placental expression of TNF-α, IL-1β, IL-6, IL-8, and IL-5 mRNA were all increased significantly in placentae of female fetuses whose mothers had mild asthma, but no changes were observed in placentae of male fetuses. The proinflammatory cytokines TNF-α, IL-1β, and IL-6 were negatively correlated with female cord blood cortisol, but there were no such correlations in placentae from males. Multivariate analysis indicated the strongest predictor of both cytokine mRNA expression in the placenta and birth weight was fetal cortisol but only in females. Placental cytokine mRNA levels were not significantly altered by inhaled glucocorticoid use, placental macrophage numbers, cigarette use, moderate-severe asthma, or male sex. These data suggest that placental basal cytokine mRNA expression is sex specifically regulated in pregnancies complicated by asthma, and interestingly these changes are more prevalent in mild rather than severe asthma. |
Keywords: | Macrophages Animals Rats Asthma Pregnancy Complications Birth Weight Pregnancy Proteins RNA, Messenger Cytokines Glucocorticoids Leukocyte Count Severity of Illness Index Smoking Pregnancy Maternal-Fetal Exchange Sex Characteristics Female |
Rights: | Copyright © 2009 by The American Association of Immunologists, Inc. |
DOI: | 10.4049/jimmunol.182.3.1411 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/252438 http://purl.org/au-research/grants/nhmrc/300786 |
Published version: | http://dx.doi.org/10.4049/jimmunol.182.3.1411 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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