Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57647
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Selective Vulnerability of Peripheral Nerves in Avian Riboflavin Deficiency Demyelinating Polyneuropathy
Author: Cai, Z.
Blumbergs, P.
Finnie, J.
Manavis, J.
Thompson, P.
Citation: Veterinary Pathology, 2009; 46(1):88-96
Publisher: Amer Coll Vet Pathologist
Issue Date: 2009
ISSN: 0300-9858
1544-2217
Statement of
Responsibility: 
Cai Z, Blumbergs PC, Finnie JW, Manavis J and Thompson PD.
Abstract: Riboflavin (vitamin B2) deficiency in young chickens produces a demyelinating peripheral neuropathy. In this study, day-old broiler meat chickens were fed a riboflavin-deficient diet (1.8 mg/kg) and killed on posthatch days 6, 11, 16, 21, and 31, while control chickens were given a conventional diet containing 5.0 mg/kg riboflavin. Pathologic changes were found in sciatic, cervical, and lumbar spinal nerves of riboflavin-deficient chickens from day 11 onwards, characterized by endoneurial oedema, hypertrophic Schwann cells, tomacula (redundant myelin swellings), demyelination/remyelination, lipid deposition, and fibroblastic onion bulb formation. Similar changes were also found in large and medium intramuscular nerves, although they were less severe in the latter. However, by contrast, ventral and dorsal spinal nerve roots, distal intramuscular nerves, and subcutaneous nerves were normal at all time points examined. These findings demonstrate, for the first time, that riboflavin deficiency in young, rapidly growing chickens produces selective injury to peripheral nerve trunks, with relative sparing of spinal nerve roots and distal nerve branches to muscle and skin. These novel findings suggest that the response of Schwann cells in peripheral nerves with riboflavin deficiency differs because either there are subsets of these cells in, or there is variability in access of nutrients to, different sites within the nerves.
Keywords: Peripheral Nerves; Animals; Chickens; Demyelinating Diseases; Polyneuropathies; Riboflavin Deficiency; Poultry Diseases; Disease Models, Animal; Tolonium Chloride
Rights: © 2009 American College of Veterinary Pathologists
RMID: 0020090060
DOI: 10.1354/vp.46-1-88
Published version: http://www.ncbi.nlm.nih.gov/pubmed/19112122
Appears in Collections:Pathology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.