Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/57888
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dc.contributor.authorFinnie, J.en
dc.contributor.authorManavis, J.en
dc.contributor.authorBlumbergs, P.en
dc.date.issued2010en
dc.identifier.citationJournal of Clinical Neuroscience, 2010; 17(2):237-240en
dc.identifier.issn0967-5868en
dc.identifier.issn1532-2653en
dc.identifier.urihttp://hdl.handle.net/2440/57888-
dc.description.abstractNon-accidental head injury (“shaken baby syndrome”) is a major cause of death and disability in infants and young children, but it is uncertain whether shaking alone is sufficient to cause brain damage or an additional head impact is required. Accordingly, we used manual shaking in an ovine model in an attempt to answer this question since lambs have a relatively large gyrencephalic brain and weak neck muscles resembling a human infant. Neuronal perikaryal and axonal reactions were quantified 6 hours after shaking using amyloid precursor protein (APP) immunohistochemistry. Neuronal perikaryal APP was widely distributed in the brain and spinal cord, the first time such a diffuse neuronal stress response after shaking has been demonstrated, but axonal immunoreactivity was minimal and largely confined to the rostral cervical spinal cord at the site of maximal loading. No ischaemic-hypoxic damage was found in haematoxylin and eosin-stained sections.en
dc.description.statementofresponsibilityJohn W. Finnie, Jim Manavis and Peter C. Blumbergsen
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/623056/description#descriptionen
dc.language.isoenen
dc.publisherChurchill Livingstoneen
dc.rightsCrown copyright © 2009 Published by Elsevier Ltd.en
dc.subjectAnimal model; Neuronal and axonal reactions; Shaken baby syndromeen
dc.titleDiffuse neuronal perikaryal amyloid precursor protein immunoreactivity in an ovine model of non-accidental head injury (the shaken baby syndrome)en
dc.typeJournal articleen
dc.identifier.rmid0020100012en
dc.identifier.doi10.1016/j.jocn.2009.07.001en
dc.identifier.pubid33881-
pubs.library.collectionPathology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Pathology publications

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