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https://hdl.handle.net/2440/57987
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Type: | Journal article |
Title: | Microglial activation as a measure of stress in mouse brains exposed acutely (60 minutes) and long-term (2 years) to mobile telephone radiofrequency fields |
Author: | Finnie, J. Cai, Z. Manavis, J. Helps, S. Blumbergs, P. |
Citation: | Pathology, 2010; 42(2):151-154 |
Publisher: | Taylor & Francis |
Issue Date: | 2010 |
ISSN: | 0031-3025 1465-3931 |
Statement of Responsibility: | John W. Finnie, Zhao Cai, Jim Manavis, Stephen Helps, Peter C. Blumbergs |
Abstract: | Aim: To determine whether acute or long-term exposure of the brain to mobile telephone radiofrequency (RF) fields produces activation of microglia, which normally respond rapidly to any change in their microenvironment. Methods: Using a purpose designed exposure system at 900 MHz, mice were given a single, far-field whole body exposure at a specific absorption rate (SAR) of 4 W/kg for 60min (acute) or on five successive days per week for 104 weeks (long-term). Control mice were sham-exposed or freely mobile in a cage to control for any stress caused by immobilisation in the exposure module. Positive control brains subjected to a stab wound were also included to confirm the ability of microglia to react to any neural stress. Brains were perfusion-fixed with 4% paraformaldehyde and representative regions of the cerebral cortex and hippocampus immunostained for ionised calcium binding adaptor molecule (Iba1), a specific microglial marker. Results: There was no increase in microglial Iba1 expression in brains short or long-term exposed to mobile telephony microwaves compared to control (sham-exposed or freely moving caged mice) brains, while substantial microglial activation occurred in damaged positive control neural tissue. Conclusion: Acute (60minutes) or longer duration (2 years) exposure of murine brains to mobile telephone RF fields did not produce any microglial activation detectable by Iba1 immunostaining. |
Keywords: | Mobile telephony brain microglial activation |
Rights: | © 2010 Royal College of Pathologists of Australasia |
DOI: | 10.3109/00313020903494086 |
Published version: | http://dx.doi.org/10.3109/00313020903494086 |
Appears in Collections: | Aurora harvest Pathology publications |
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