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Type: Journal article
Title: Effect of long-term mobile communication microwave exposure on vascular permeability in mouse brain
Author: Finnie, J.
Blumbergs, P.
Manavis, J.
Utteridge, T.
Gebski, V.
Davies, R.
Vernon-Roberts, B.
Kuchel, T.
Citation: Pathology, 2002; 34(4):344-347
Publisher: Carfax Publishing
Issue Date: 2002
ISSN: 0031-3025
Abstract: AIMS:To study the effect of long-term exposure to global system for mobile communication (GSM) radiofrequency fields on vascular permeability in murine brains. METHODS:Using a purpose-designed exposure system at 900 MHz, mice were given a 60-minute far-field, whole body exposure on each of 5 days per week for 104 weeks at specific absorption rates (SAR) of 0.25, 1.0,2.0 and 4.0 W/kg. Control mice were sham-exposed or permitted free movement in a cage to evaluate any stress-related effects. Albumin immunohistochemistry was used to detect increased vascular permeability and the efficacy of the vascular tracer was confirmed with a positive control group exposed to a clostridial toxin known to increase vascular permeability in the brain. RESULTS:In all exposed and control groups, albumin extravasation was minimal, often leptomeningeal, and was deemed insignificant as a maximum of three capillaries or venules in a given brain showed leakage from the very many blood vessels present in the three coronal brain sections. CONCLUSIONS:These results suggest that prolonged exposure to mobile telephone-type radiation produces negligible disruption to blood-brain barrier integrity at the light microscope level using endogenous albumin as a vascular tracer.
Keywords: Animals; Mice, Inbred C57BL; Mice; Serum Albumin; Immunohistochemistry; Capillary Permeability; Cerebrovascular Circulation; Microwaves; Female; Cell Phone
RMID: 0020020330
DOI: 10.1080/003130202760120517
Appears in Collections:Pathology publications

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