Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats|
|Citation:||International Journal of Neuropsychopharmacology, 2009; 12(06):731-736|
|Publisher:||Cambridge Univ Press|
|Department:||Clinical and Experimental Pharmacology|
|Charles P. France, Jun-Xu Li, William A. Owens, Wouter Koek, Glenn M. Toney and Lynette C. Daws|
|Abstract:||Efficacy of antidepressant drugs is often limited. One of the limiting factors may be diet. This study shows that the effect of escitalopram in the forced swimming test is diminished in rats by food restriction that decreased body weight by 8%. The primary target for escitalopram is the serotonin (5-HT) transporter. Using high-speed chronoamperometry to measure 5-HT clearance in vivo in rats fed the same foodrestricted diet, the rate of 5-HT clearance from extracellular fluid in brain was dramatically increased. Increased 5-HT transporter function under conditions of dietary restriction might contribute to the decreased effect of escitalopram. These results suggest that diet plays an integral role in determining efficacy of antidepressant drugs, and might well generalize to other psychoactive drugs that impinge upon the 5-HT transporter.|
|Keywords:||Antidepressant; rat; serotonin; serotonin transporter; SSRI|
|Rights:||Copyright © CINP 2009|
|Appears in Collections:||Pharmacology publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.