Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/58082
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Type: Journal article
Title: Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats
Author: France, C.
Li, J.
Owens, W.
Koek, W.
Toney, G.
Daws, L.
Citation: International Journal of Neuropsychopharmacology, 2009; 12(06):731-736
Publisher: Cambridge Univ Press
Issue Date: 2009
ISSN: 1461-1457
1469-5111
Department: Clinical and Experimental Pharmacology
Statement of
Responsibility: 
Charles P. France, Jun-Xu Li, William A. Owens, Wouter Koek, Glenn M. Toney and Lynette C. Daws
Abstract: Efficacy of antidepressant drugs is often limited. One of the limiting factors may be diet. This study shows that the effect of escitalopram in the forced swimming test is diminished in rats by food restriction that decreased body weight by 8%. The primary target for escitalopram is the serotonin (5-HT) transporter. Using high-speed chronoamperometry to measure 5-HT clearance in vivo in rats fed the same foodrestricted diet, the rate of 5-HT clearance from extracellular fluid in brain was dramatically increased. Increased 5-HT transporter function under conditions of dietary restriction might contribute to the decreased effect of escitalopram. These results suggest that diet plays an integral role in determining efficacy of antidepressant drugs, and might well generalize to other psychoactive drugs that impinge upon the 5-HT transporter.
Keywords: Antidepressant; rat; serotonin; serotonin transporter; SSRI
Rights: Copyright © CINP 2009
RMID: 0020096116
DOI: 10.1017/S1461145709000418
Appears in Collections:Pharmacology publications

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