Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/58116
Type: Conference paper
Title: A study of cortical bone microdamage and crack morphology utilising confocal microscopy and sequential labelling
Author: Codrington, J.
Kuliwaba, J.
Zarrinkalam, K.
Fazzalari, N.
Citation: Proceedings of the International Conference on Crack paths (CP 2009) Vicenza (Italy), 23–25 September 2009.
Publisher: ESIS
Publisher Place: Italy
Issue Date: 2009
Conference Name: International Conference on Crack Paths (2009 : Vicenza, Italy)
Statement of
Responsibility: 
J. Codrington, J. Kuliwaba, K. Zarrinkalam and N. Fazzalari
Abstract: The formation and accumulation of microdamage in bone plays an important role in the occurrence of stress and fragility fractures as well as in the initiation of bone remodelling. In this study a novel technique is presented for the investigation of bone microdamage and crack morphology using laser scanning confocal microscopy and sequential labelling with chelating fluorochromes. Compact tension fracture specimens machined from bovine tibial cortical bone, were mechanically tested in a wedge loaded crack-propagating tool. Sequential labelling with xylenol orange and calcein allowed for the crack propagation and microdamage progression to be assessed at each stage using confocal microscopy. Both twodimensional confocal images and three-dimensional z-series reconstructions displayed the formation of a microdamage process zone and wake surrounding the main crack. Further imaging demonstrated the significance of the bone microstructure, such as the vasculature and osteocytes, in the distribution of the microdamage.
Rights: Copyright status unknown
RMID: 0020096501
Description (link): http://www.cp2009.unipr.it/
http://www.gruppofrattura.it/index.php?option=com_jombib&task=showbib&id=1051
Appears in Collections:Mechanical Engineering conference papers
Materials Research Group publications

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