Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/58387
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Type: Journal article
Title: Genetic influences on the pharmacokinetics of orally and intravenously administered Digoxin as exhibited by monozygotic twins
Author: Birkenfeld, A.
Jordan, J.
Hofmann, U.
Busjahn, A.
Franke, G.
Kruger, N.
Igel, S.
Murdter, T.
Drescher, S.
Shi, S.
Engeli, S.
Schwab, M.
Eichelbaum, M.
Luft, F.
Fromm, M.
Citation: Clinical Pharmacology & Therapeutics, 2009; 86(6):605-608
Publisher: Mosby Inc
Issue Date: 2009
ISSN: 0009-9236
1532-6535
Statement of
Responsibility: 
A. L. Birkenfeld, J. Jordan, U. Hofmann, A. Busjahn, G. Franke, N. Krüger, S. Igel, T. Mürdter, S. Drescher, S. Shi, S. Engeli, M. Schwab, M. Eichelbaum, F. C. Luft and M. F. Fromm
Abstract: The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.
Keywords: Humans; Deuterium; Digoxin; P-Glycoprotein; Administration, Oral; Infusions, Intravenous; Registries; Pilot Projects; Twins, Monozygotic; Genotype; Phenotype; Adult; Female; Male; Genetic Variation; Young Adult
Rights: Copyright © 2009, Nature Publishing Group
RMID: 0020096554
DOI: 10.1038/clpt.2009.170
Appears in Collections:Pharmacology publications

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