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|Title:||Genetic influences on the pharmacokinetics of orally and intravenously administered Digoxin as exhibited by monozygotic twins|
|Citation:||Clinical Pharmacology & Therapeutics, 2009; 86(6):605-608|
|A. L. Birkenfeld, J. Jordan, U. Hofmann, A. Busjahn, G. Franke, N. Krüger, S. Igel, T. Mürdter, S. Drescher, S. Shi, S. Engeli, M. Schwab, M. Eichelbaum, F. C. Luft and M. F. Fromm|
|Abstract:||The expression and function of the drug transporter P-glycoprotein are highly variable. Environmental and genetic factors contribute to this variation. We studied the disposition of digoxin, a frequently used probe drug for P-glycoprotein function in humans, in monozygotic (MZ) twins and found that digoxin pharmacokinetics after oral and intravenous administration are highly correlated within MZ twins, supporting the hypothesis of a robust contribution from genetic variance. Our study suggests that studies involving twins could be more widely applied to elucidate pharmacogenetics.|
|Keywords:||Humans; Deuterium; Digoxin; P-Glycoprotein; Administration, Oral; Infusions, Intravenous; Registries; Pilot Projects; Twins, Monozygotic; Genotype; Phenotype; Adult; Female; Male; Genetic Variation; Young Adult|
|Rights:||Copyright © 2009, Nature Publishing Group|
|Appears in Collections:||Pharmacology publications|
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