Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5975
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dc.contributor.authorMilne, R.en
dc.contributor.authorMcLean, C.en
dc.contributor.authorMather, L.en
dc.contributor.authorNation, R.en
dc.contributor.authorRunciman, W.en
dc.contributor.authorRutten, A.en
dc.contributor.authorSomogyi, A.en
dc.date.issued1995en
dc.identifier.citationDrug Metabolism and Disposition, 1995; 23(3):334-342en
dc.identifier.issn0090-9556en
dc.identifier.issn1521-009Xen
dc.identifier.urihttp://hdl.handle.net/2440/5975-
dc.description.abstractThe disposition of morphine-3-glucuronide (M3G) in sheep was compared during separate constant infusions of morphine and M3G. Five ewes received a 15-min loading dose, followed by a constant infusion of morphine sulfate (10 mg/hr) or M3G (4 mg/hr for 4 sheep, 7.5 mg/hr for 1 sheep) for a further 5.75 hr. During the 5th-6th hr of infusion, blood was collected simultaneously from the aorta, pulmonary artery, hepatic vein, hepatic portal vein, renal vein, and posterior vena cava. Additional samples were collected from the aorta from 0 to 5 hr and from 6 to 48 hr. Urine was collected via an indwelling catheter from 0 to 6 hr, with further free-flowing urine up to 48 hr. An HPLC assay was used to determine simultaneously morphine, M3G, and morphine-6-glucuronide (M6G) in plasma and urine. Constant concentrations of morphine, M3G, and M6G in plasma were achieved during the 5- to 6-hr period of infusion with morphine, as were the concentrations of M3G while M3G was infused. Regional net extraction ratios and total and regional clearances were calculated during the 5- to 6-hr period. After the infusions were ceased, there was prolonged elimination of M3G formed in situ from morphine compared to when infused as M3G. No morphine or M6G was detected in the plasma during and after infusion with M3G, nor were they found in urine collected up to 6 hr.(ABSTRACT TRUNCATED AT 250 WORDS)en
dc.language.isoenen
dc.publisherAmerican Society for Pharmacology & Experimental Therapeutics etc.en
dc.subjectLiver; Kidney; Animals; Sheep; Morphine; Morphine Derivatives; Metabolic Clearance Rate; Infusions, Intravenous; Femaleen
dc.titleComparative disposition of morphine-3-glucuronide during separate intravenous infusions of morphine and morphine-3-glucuronide in sheep: Importance of the kidneyen
dc.typeJournal articleen
dc.identifier.rmid0030006087en
dc.identifier.pubid70093-
pubs.library.collectionAnaesthesia and Intensive Care publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Anaesthesia and Intensive Care publications

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