Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/5983
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dc.contributor.authorOng, J.en
dc.contributor.authorKerr, D.en
dc.contributor.authorBowden, J.en
dc.contributor.authorPrager, R.en
dc.date.issued1999en
dc.identifier.citationEuropean Journal of Pharmacology, 1999; 367(2-3):207-211en
dc.identifier.issn0014-2999en
dc.identifier.issn1879-0712en
dc.identifier.urihttp://hdl.handle.net/2440/5983-
dc.description.abstractCholinergic twitch responses in the guinea-pig isolated ileum, and spontaneous discharges in rat neocortical slices, were depressed by the GABA(B) receptor agonist baclofen. These actions were reversibly antagonised by the sulphonamide derivatives (R,S)-2-hydroxy-3-phthalimidopropanesulphonamide (HPIPS), 3-amino-N-benzoylpropanesulphonamide (ABPS) and 3-phthalimidopropanesulphonamide (PIPS) which produced rightwards shifts of the baclofen concentration-response curves, with pA2 values ranging between 4.1 and 4.3 in both preparations. From these results, HPIPS, ABPS and PIPS constitute a novel class of antagonists at GABA(B) hetero-receptors.en
dc.language.isoenen
dc.subjectMuscle, Smooth; Ileum; Neocortex; Animals; Guinea Pigs; Rats; Rats, Sprague-Dawley; Sulfonamides; gamma-Aminobutyric Acid; Baclofen; GABA Agonists; GABA Antagonists; Drug Interactions; Male; GABA-B Receptor Antagonists; In Vitro Techniquesen
dc.titleEvaluation of 3-aminopropanesulphonamide analogues of GABA as antagonists at GABA (B) receptors in peripheral and central preparationsen
dc.typeJournal articleen
dc.identifier.rmid0030006085en
dc.identifier.doi10.1016/S0014-2999(98)00962-5en
dc.identifier.pubid70091-
pubs.library.collectionAnaesthesia and Intensive Care publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidOng, J. [0000-0002-0958-460X]en
Appears in Collections:Anaesthesia and Intensive Care publications

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