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https://hdl.handle.net/2440/5985
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Kerr, D. | - |
dc.contributor.author | Ong, J. | - |
dc.contributor.author | Doolette, D. | - |
dc.contributor.author | Schafer, K. | - |
dc.contributor.author | Prager, R. | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | European Journal of Pharmacology, 1995; 287(2):185-189 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/5985 | - |
dc.description.abstract | In the guinea-pig isolated ileum, (RS)-(+/-)-baclofen induced a depression of cholinergic twitch contractions, reversibly and competitively antagonised by (S)-2-hydroxysaclofen (pA2 = 5.2 +/- 0.2), but not by (R)-2-hyroxysaclofen. The depression of excitatory field potentials by baclofen ( 5 mu M) in rat CA1 hippocampal slices was antagonised by (S)-2-hydroxysaclofen (100 mu m) (pA2 = 4.3), whilst in rat neocortex, (S)-2-hyroxysaclofen (50-500 mu M) antagonised the baclofen (10 mu M)-induced suppression of spontaneous discharges, the (R)-enantiomer being inactive. These results show that (S)-2-hydroxysaclofen is the active antagonist at central and peripheral GABAB receptors. | - |
dc.language.iso | en | - |
dc.publisher | Elsevier | - |
dc.rights | © 1995 Elsevier Science B.V. All rights reserved | - |
dc.source.uri | http://dx.doi.org/10.1016/0014-2999(95)00641-9 | - |
dc.subject | GABAB receptor | - |
dc.subject | (RS)-(±)-Baclofen | - |
dc.subject | (S)-2-Hydroxysaclofen | - |
dc.subject | (R)-2-Hydroxysaclofen | - |
dc.subject | Ileum, guinea pig | - |
dc.subject | Hippocampus, rat | - |
dc.subject | Neocortex, rat | - |
dc.title | The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/0014-2999(95)00641-9 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ong, J. [0000-0002-0958-460X] | - |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest |
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