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https://hdl.handle.net/2440/5986
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Type: | Journal article |
Title: | Interactions of N-ethylmaleimide and aluminium fluoride with GABAB receptor function in rat neocortical slices |
Author: | Ong, J. Kerr, D. |
Citation: | European Journal of Pharmacology, 1995; 287(2):197-200 |
Publisher: | North Holland |
Issue Date: | 1995 |
ISSN: | 0014-2999 1879-0712 |
Abstract: | Interactions of N-ethylmaleimide and aluminium fluoride (AlF - 4) with GABAB receptors have been examined using spontaneously discharging rat neocortical slices. The suppression of discharges by the GABAB receptor agonist baclofen (5-10 mu M) was irreversibly prevented by N-ethylmaleimide (10-50 mu M) and its analog N-phenylmaleimide (10-50 mu M), whilst superfusion of slices with NaF (10 mM) and AlCl3 (100 mu M) to form a fluoroaluminate (AlF - 4) complex markedly potentiated the action of baclofen. The lipoxygenase inhibitors, nordihydroguaiaretic acid (10-50 mu M) and eicosatetraynoic acid (10-50 mu M) or the phospholipase A2 inhibitor bromophenacylbromide (50-100 mu M) did not affect the response to baclofen. The depressant action of baclofen is evidently mediated through G-proteins, but is not dependent on arachidonic acid metabolites. |
Keywords: | Cerebral Cortex Animals Rats Rats, Sprague-Dawley Aluminum Compounds Baclofen Ethylmaleimide Receptors, GABA-B Membrane Potentials Drug Interactions Male |
DOI: | 10.1016/0014-2999(95)00659-1 |
Published version: | http://dx.doi.org/10.1016/0014-2999(95)00659-1 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest 5 |
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