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|Title:||3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations|
|Citation:||European Journal of Pharmacology, 1995; 294(1):349-352|
|Abstract:||Racemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the concentration-dependent depression of cholinergic twitch contractions by baclofen, in the electrically stimulated guinea-pig isolated ileum, with a pA2 of 4.0 +/- 0.2. In the rat neocortex, maintained in Mg(2+)-free medium, AHPNS (100-500 microM) also reversibly antagonised the baclofen (10 microM)-induced suppression of spontaneous discharges. AHPNS is a new class of GABAB receptor antagonist that has central and peripheral blocking actions.|
|Keywords:||Muscle, Smooth; Ileum; Central Nervous System; Cerebral Cortex; Peripheral Nervous System; Parasympathetic Nervous System; Animals; Guinea Pigs; Rats; Rats, Sprague-Dawley; Magnesium; Sulfonamides; Baclofen; GABA Agonists; Electric Stimulation; Muscle Contraction; Male; GABA-B Receptor Agonists; GABA-B Receptor Antagonists|
|Appears in Collections:||Anaesthesia and Intensive Care publications|
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