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https://hdl.handle.net/2440/5987
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Type: | Journal article |
Title: | 3-Amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide, a new class of GABAB receptor antagonist in central and peripheral preparations |
Author: | Kerr, D. Ong, J. Hughes, R. Prager, R. |
Citation: | European Journal of Pharmacology, 1995; 294(1):349-352 |
Publisher: | North Holland |
Issue Date: | 1995 |
ISSN: | 0014-2999 1879-0712 |
Abstract: | Racemic 3-amino-2-hydroxy-N-(4-nitrophenyl)-propanesulphonamide (AHPNS), a sulphonamide analog of GABA, reversibly and competitively antagonised the concentration-dependent depression of cholinergic twitch contractions by baclofen, in the electrically stimulated guinea-pig isolated ileum, with a pA2 of 4.0 +/- 0.2. In the rat neocortex, maintained in Mg(2+)-free medium, AHPNS (100-500 microM) also reversibly antagonised the baclofen (10 microM)-induced suppression of spontaneous discharges. AHPNS is a new class of GABAB receptor antagonist that has central and peripheral blocking actions. |
Keywords: | Muscle, Smooth Ileum Central Nervous System Cerebral Cortex Peripheral Nervous System Parasympathetic Nervous System Animals Guinea Pigs Rats Rats, Sprague-Dawley Magnesium Sulfonamides Baclofen GABA Agonists Electric Stimulation Muscle Contraction Male GABA-B Receptor Agonists GABA-B Receptor Antagonists In Vitro Techniques |
DOI: | 10.1016/0014-2999(95)00688-5 |
Published version: | http://dx.doi.org/10.1016/0014-2999(95)00688-5 |
Appears in Collections: | Anaesthesia and Intensive Care publications Aurora harvest |
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