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Type: Journal article
Title: Inhibition of apoptosis in periodontitis
Author: Lucas, H.
Bartold, P.
Dharmapatni, A.
Holding, C.
Haynes, D.
Citation: Journal of Dental Research, 2010; 89(1):29-33
Publisher: Inter Amer Assoc Dental Research
Issue Date: 2010
ISSN: 0022-0345
Statement of
H. Lucas, P.M. Bartold, A.A.S.S.K. Dharmapatni, C.A. Holding and D.R. Haynes
Abstract: This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members. Gingival tissue samples were taken from healthy individuals and those with chronic periodontitis. The expression of TRAIL, TRAIL receptors, TUNEL, cleaved caspase-3, xIAP, and survivin was determined immunohistologically and at the level of mRNA expression. Higher levels of TRAIL and the TRAIL decoy receptor, TRAIL R4, were expressed in the diseased periodontal tissues (p < 0.005). Statistically (p < 0.05) higher levels of cleaved caspase-3 and the cleaved caspase-3 inhibitors, xIAP and survivin, were seen. Similar changes were seen at the level of mRNA. The results indicate that apoptosis in periodontitis may be inhibited by elevated expression of TRAIL decoy receptors and cleaved caspase-3 inhibitors.
Keywords: apoptosis; TRAIL; caspase-3; xIAP; survivin.
Rights: Copyright © 2010 by International & American Associations for Dental Research
RMID: 0020094311
DOI: 10.1177/0022034509350708
Appears in Collections:Pathology publications

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