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https://hdl.handle.net/2440/60706
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Type: | Journal article |
Title: | Effect of treatment of gestational diabetes mellitus on obesity in the next generation |
Author: | Gillman, M. Oakey, H. Baghurst, P. Volkmer, R. Robinson, J. Crowther, C. |
Citation: | Diabetes Care, 2010; 33(5):964-968 |
Publisher: | Amer Diabetes Assoc |
Issue Date: | 2010 |
ISSN: | 0149-5992 1935-5548 |
Statement of Responsibility: | Matthew W. Gillman, Helena Oakey, Peter A. Baghurst, Robert E. Volkmer, Jeffrey S. Robinson and Caroline A. Crowther |
Abstract: | OBJECTIVE--Gestational diabetes mellitus (GDM) may cause obesity in the offspring. The objective was to assess the effect of treatment for mild GDM on the BMI of 4- to 5-year-old children. RESEARCH DESIGN AND METHODS--Participants were 199 mothers who participated in a randomized controlled trial of the treatment of mild GDM during pregnancy and their children. Trained nurses measured the height and weight of the children at preschool visits in a state-wide surveillance program in the state of South Australia. The main outcome measure was age- and sex-specific BMI Z score based on standards of the International Obesity Task Force. RESULTS--At birth, prevalence of macrosomia (birth weight [greater than or equal to] 4,000 g) was 5.3% among the 94 children whose mothers were in the intervention group, and 21.9% among the 105 children in the routine care control group. At 4- to 5-years-old, mean (SD) BMI Z score was 0.49 (1.20) in intervention children and 0.41 (1.40) among controls. The difference between treatment groups was 0.08 (95% CI -0.29 to 0.44), an estimate minimally changed by adjustment for maternal race, parity, age, and socio-economic index (0.08 [-0.29 to 0.45]). Evaluating BMI [greater than or equal to] 85th percentile rather than continuous BMI Z score gave similarly null results. CONCLUSIONS--Although treatment of GDM substantially reduced macrosomia at birth, it did not result in a change in BMI at age 4- to 5-years-old. |
Keywords: | Humans Diabetes, Gestational Fetal Macrosomia Prenatal Exposure Delayed Effects Obesity Insulin Hypoglycemic Agents Body Mass Index Prevalence Follow-Up Studies Pregnancy Child, Preschool South Australia Female Male |
Rights: | COPYRIGHT 2010 American Diabetes Association |
DOI: | 10.2337/dc09-1810 |
Published version: | http://dx.doi.org/10.2337/dc09-1810 |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
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