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Type: Journal article
Title: Optical sensors based on whispering gallery modes in fluorescent microbeads: response to specific interactions
Author: Himmelhaus, M.
Krishnamoorthy, S.
François, A.
Citation: Sensors, 2010; 10(6):6257-6274
Publisher: Molecular Diversity Preservation International (MDPI)
Issue Date: 2010
ISSN: 1424-8220
Statement of
Michael Himmelhaus, Sivashankar Krishnamoorthy and Alexandre Francois
Abstract: Whispering gallery modes (WGMs) in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing the formation of biochemical adsorption layers on their outer surface with the well-established biotin-streptavidin specific binding as the model system. Three different methods for analysis of the observed shifts in the WGM wavelength positions are applied and used to quantify the adsorbed mass densities, which are then compared with the results of a comparative surface plasmon resonance (SPR) study.
Keywords: whispering gallery modes; cavity modes; optical sensing; refractive index sensing; biosensing; label-free detection
Rights: © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (
RMID: 0020100329
DOI: 10.3390/s100606257
Appears in Collections:Physics publications

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