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|Title:||Role of spiral wave pinning in inhomogeneous active media in the termination of atrial fibrillation by electrical cardioversion|
|Citation:||Computers in Biology and Medicine, 2010; 40(3):363-372|
|Publisher:||Pergamon-Elsevier Science Ltd|
|Pawel Kuklik, Christopher X. Wong, Anthony G. Brooks, Jan Jacek Żebrowski, Prashanthan Sanders|
|Abstract:||Atrial fibrillation is the most common type of arrhythmia to affect humans. One of the treatment modalities for atrial fibrillation is an electrical cardioversion. Electrical cardioversion can result in one of three outcomes: an immediate termination of arrhythmic activity, a delayed termination or unsuccessful termination. The mechanism of delayed termination is unknown. Here we present a model of an atrial fibrillation as a coexistence of several spiral waves pinned to the inhomogeneities in active media. We show that in inhomogeneous system delayed termination can be explained as the unpinning of a spiral wave from inhomogeneities and its termination after collision with the edge of the system.|
|Keywords:||Excitable media; Spiral wave pinning; Electrical cardioversion; Atrial fibrillation; Arrhythmia mechanisms|
|Rights:||© 2010 Elsevier Ltd. All rights reserved.|
|Appears in Collections:||Medicine publications|
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